CAS: 331947-44-5; (S)-(-)-Tolvaptan

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(S)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine MOP-21826 (S)-7-chloro-5-methoxymethyloxy-2,3,4,5-tetrahydro-1H-1-benzazepine (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

📜7-氯-1-[2-甲基-4-[(2-甲基苯甲酰)氨基]苯甲酰基]-5-氧代-2,3,4,5-四氢-1H-1-苯并氮杂卓置于sodium Formate体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 36.0H,以80.4%的收率获得(S)-(-)-托伐普坦
参考文献:Efficient Biosynthesis Of Enantiopure Tolvaptan By Utilizing Alcohol Dehydrogenase-Catalyzed Enantioselective Reduction
标题:Efficient Biosynthesis Of Enantiopure Tolvaptan By Utilizing Alcohol Dehydrogenase-Catalyzed Enantioselective Reduction
摘要:使用共表达酒精脱氢酶(psadh)和甲酸脱氢酶(cpfdh)的大肠杆菌整细胞,在双相水-大豆油系统中生物合成对映纯度高的托瓦普坦被证明是一种高效的方法.
Doi:10.1039/c7Gc03679E