CAS: 328956-61-2; 3-Chloro-5-Fluorophenylboronic Acid

上下游产品

CAS号121-43-7 硼酸三甲酯 | CAS号33863-76-2 1-溴-3-氯-5-氟苯

1-溴-3-氯-5-氟苯置于盐酸,正丁基锂体系中,用 四氢呋喃 用作溶剂,化学反应生成3-氯-5-氟苯硼酸
参考文献:Pyridone-Containing Farnesyltransferase Inhibitors: Synthesis And Biological Evaluation
标题:Pyridone-Containing Farnesyltransferase Inhibitors: Synthesis And Biological Evaluation
摘要:Farnesyltransferase Inhibitors (Ftis) Have Been Developed As Potential Anti-Cancer Agents Due To Their Efficacy In Blocking Malignant Growth In A Variety Of Murine Models Of Human Tumors. To That End,We Have Developed A Series Of Pyridone Farnesyltransferase Inhibitors With Potent In Vitro And Cellular Activity. The Synthesis,Sar And Biological Properties Of These Compounds Will Be Discussed. (C) 2003 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2003.08.058

专利信息

专利号:US-7696246-B2
优先权日:1999-08-27
标题:Bicyclic androgen and progesterone receptor modulator compounds and methods
发明人：ZHI LIN; VAN OEVEREN CORNELIS ARJAN; MARTINBOROUGH ESTHER
权利人:LIGAND PHARM INC
摘要:The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.