CAS: 3228-99-7; Pentaerythrityl Tetrachloride

该化合物是一种氯化有机化合物,其结构特征是其结构,包括与丙烷主干体第一和第二个碳原子相连的两个氯原子,以及第二碳的另外两个氯甲基组;该化合物一般没有色素,可粉黄液体,以其密度高和低挥发性而著称;该化合物在水中不溶解,但在有机溶剂中可溶解,因而在各种化学应用中有用;多氯原子的存在有助于其再活动,特别是在核分裂替代反应中,由于其氯化性质,它可能对环境和健康造成危害,需要小心处理和处置;该化合物通常用于其他化学化合物的合成,并可作为生产农业化学品或药品的中间体;在与该物质打交道时,安全防范是不可或缺的,因为如果吸入或摄取,它可能具有危险性.

结构式图片

相似化合物

1067-09-0 753-89-9 29559-55-5

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上下游产品

diazomethane tetrachloromethane pyridine Pentaerythritol1,1,2,3,3-pentachloro-1-propene 1,1,1,2,2,3,3-heptachloropropane perchloropropene 1,3,3-Trichlor-2-dichlormethyl-propen-(1)

合成工艺路线路线简述

  • 115-77-5 = 3228-99-7 + 813-99-0 [标题:Reaction Conditions
    标题:Synthesis By Substitution Of Oxygen Functionalities
    作者:Margaretha,P.
    参考文献:Science Of Synthesis 日期:2007 卷标:35 页码:63-94]

    115-77-5 = 3228-99-7 + 813-99-0
    反应条件:1.1 Reagents: Pyridine,Thionyl Chloride; 2 H,65 - 95 °C; 5 - 6 H,95 °C -> 120 °C; 16 H,Reflux
    标题:Synthesis Of 3-Chloro-2-Chloromethylpropene
    作者:Chen,Shao-Rui; Et Al
    参考文献:Hecheng Huaxue 日期:2004 卷标:12(5) 页码:425-426]

    115-77-5 = 3228-99-7 + 813-99-0
    反应条件:1.1 Reagents: Pyridine,Thionyl Chloride
    标题:Improved Preparations Of 3-Chloro-2-(Chloromethyl)-1-Propene And 1,1-Dibromo-2,2-Bis(Chloromethyl)Cyclopropane: Intermediates In The Synthesis Of [1.1.1]Propellane
    作者:Lynch,Kathleen Mondanaro; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(14) 页码:4666-8

海关参考信息

专利信息


专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人:FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-7615169-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人:STROUSE GEOFFREY FIELDING; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.

专利号:US-6184168-B1
优先权日:1997-09-22
标题:Synthesis of 1,4-trans-polybutadiene using a lanthanide organic acid salt catalyst
发明人:LYNCH THOMAS J
权利人:BRIDGESTONE CORP
摘要:The invention provides a catalyst composition, comprising: (a) an organolithium compound; and, (b) an organic acid salt of lanthanide series element; wherein: (1) only components (a) and (b) are required to promote the synthesis of 1,4-trans-polybutadiene; (2) the ratio of component (a) to component (b) is selected to maximize formation of the trans structure of said 1,4-trans-polybutadiene; and, (3) components (a) and (b) are selected for enabling further diblock synthesis. The invention further contemplates a process for using the catalyst to synthesize 1,4-trans-polybutadiene and other polymers and copolymers having trans configuration in the conjugated diene monomer contributed units.

专利号:US-7927516-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人:STROUSE GEOFFREY F; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.

专利号:US-6423877-B1
优先权日:1999-11-15
标题:Synthesis of pseudopterosin compounds
发明人:COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to a new synthetic route to pseudopterosin aglycone (3): n a key intermediate for the synthesis of a group of antiinflammatory natural products including pseudopterosin A (1) and E (2). The pathway of synthesis starts with the abundant and inexpensive (S)-(−)-limonene and its long-known cyclic hydroboration product (4) and leads to the chiral hydroxy ketone (6). Conversion of (6) to (10) followed by a novel aromatic annulation produced (15) which underwent highly diastereoselective cyclization to afford the protected pseudopterosin aglycone (16). The naturally occurring pseudopterosins such as (1) and (2) are readily available from this key intermediate.

专利号:US-5723619-A
优先权日:1997-01-13
标 题 :Method for the synthesis of deoxypyridinoline
发明人:HATCH ROBERT P
权利人:BAYER AG
摘要:Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a Nα-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.

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合成参考文献


参考文献:10.3390/ijms12064053
摘要:Tien YC, Liao JC, Chiu CS, Huang TH, Huang CY, Chang WT, Peng WH. Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. Int J Mol Sci. 2011;12(6):4053–67.
参考文献:10.1155/2011/238513
摘要:Franko J, Jackson LG, Meade BJ, Anderson SE. Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model. J Allergy (Cairo). 2011;2011():238513.
参考文献:10.1107/s1600536811010580
摘要:Meng FJ, Zhao CQ. 2-Isopropyl-5-methyl-cyclo-hexyl diphenyl-phospho-namidate. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o998.
参考文献:10.1107/s1600536811015546
摘要:Song XW, Xue RT, Chen SG, Yin YS. Bis(4-acetyl-anilinium) hexa-chlorido-stannate(IV). Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):m653.
参考文献:10.1107/s1600536811012864
摘要:Liu L, Meng F, Xu H, Wang D, Zhao C. N-tert-ButylO-2-isopropyl-5-methylcyclohexyl phenylphosphonamidate. Acta Crystallogr E Struct Rep Online. 2011 Apr 29;67(5):o1244. doi: 10.1107/s1600536811012864.
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