CAS: 2967-66-0; Methyl 4-(Trifluoromethyl)Benzoate

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CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号67-56-1 甲醇 | CAS号107-31-3 甲酸甲酯 | CAS号402-43-7 对溴三氟甲苯 | CAS号201230-82-2 carbon monoxide | CAS号455-13-0 4-碘三氟甲苯 | CAS号887144-97-0 3,3-二甲基-1-(三氟甲基... | CAS号99768-12-4 4-甲酯基苯硼酸 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号612493-95-5 methyl 3-hydrox... | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号339-59-3 4-(三氟甲基)苯甲酰肼 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号196934-20-0 tert-butyl 4-(t... | CAS号79-20-9 乙酸甲酯 | CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号2252-62-2 2-(4-(三氟甲基)苯基)丙醇 | CAS号71682-94-5 4-三氟甲基苯甲酰基乙腈

4-三氟甲基苯甲酸置于氯化亚砜,硫酸,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 0.18H,反应生成4-(三氟甲基)苯甲酸甲酯
参考文献:布朗斯台德酸催化的芳族羧酸氯化
标题:布朗斯台德酸催化的芳族羧酸氯化
摘要:摘要 通过与作为催化剂的布朗斯台德酸反应,已经有效地进行了芳族羧酸与 Socl 2的氯化.基于这一发现,开发了一种比传统催化方法更便宜的高效催化方法.20 种底物被氯化,在很短的反应时间内提供了极好的收率.并且socl 2 /brønsted酸体系已用于更大规模的制备反应.提出了双重活化机制来证明socl 2 /brønsted酸不可替代的体系.
Doi:10.1080/10426507.2021.1903008

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:US-7745626-B2
优先权日:2002-03-29
标 题 :Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
发明人：WU WENXUE; LIAO HONGBIAO; TSAI DAVID J; ANDREWS DAVID R; GALA DINESH; LEE GARY M; SCHWARTZ MARTIN LAWRENCE; MCALLISTER TIMOTHY L; FU XIAOYONG; MALONEY DONAL; THIRUVENGADAM TIRUVETTIPURAM K; TANN CHOU-HANG
权利人:SCHERING CORP
摘要:In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:

专利号:MX-2015001935-A
优先权日:2012-08-13
标 题 :INTERMEDIARY FOR SYNTHESIS OF 1- (2-DEOXI-2-FLUORO-4-TIO-BETA-D-A RABINOFURANOSIL) CITOSINE, INTERMEDIARY FOR SYNTHESIS OF TIONUCLEOSIDE AND METHODS TO PRODUCE THESE INTERMEDIARIES.

专利号:WO-2009091832-A1
优先权日:2008-01-14
标题 :Synthesis of pyrazoles

专利号:US-9744154-B2
优先权日:2010-03-23
标题:Polymorphic forms of ST-246 and methods of preparation
发明人：TYAVANAGIMATT SHANTHAKUMAR R; ANDERSON MELIALANI A C L S; WEIMERS WILLIAM C; NELSON DYLAN; BOLKEN TOVE′ C; HRUBY DENNIS E; O'NEILL MICHAEL H; SWEETAPPLE GARY; MCCLOUGHAN KELLEY A
权利人:SIGA TECH INC
摘要:Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.