CAS: 270263-05-3; (S)-3-Amino-4-(Furan-2-yl)Butanoic Acid

该化合物是一种氨酸衍生物,其特点是有一只呋喃环和附着在丁诺酸脊柱上的氨基酸组,这种化合物通常具有氨基酸的特性,例如形成Zwitters的能力,它们是可以同时作为酸和碱的二极离子. 呋喃环有助于其独特的再活性和潜在生物活动,使其对医药化学和药物设计感兴趣.S)的命名表明,它具有特定的空间安排,能够影响它与生物目标的相互作用.此外,这种化合物由于其功能组,在极地溶剂中可能出现溶性,其结构特征可能允许氢结合,影响它的物理特性和再活性.

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270263-07-5 110772-46-8 332061-94-6

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      专利号:US-2022243244-A1
      优先权日:2019-10-10
      标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
      发明人:ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
      权利人:SCRIPPS RESEARCH INST
      摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

      专利号:US-2023037284-A9
      优先权日:2018-11-30
      标题:Combination therapy of peptidomimetic macrocycles
      发明人:GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
      权利人:AILERON THERAPEUTICS INC
      摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

      专利号:US-9574189-B2
      优先权日:2005-12-01
      标题:Enzymatic encoding methods for efficient synthesis of large libraries
      发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
      权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
      摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

      专利号:US-2025084410-A1
      优先权日:2015-01-12
      标 题:Incorporation of unnatural nucleotides and methods thereof
      发明人:PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
      权利人:SYNTHORX INC
      摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

      专利号:US-2018371021-A1
      优先权日:2017-05-11
      标 题 :Peptidomimetic macrocycles and uses thereof
      发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
      权利人:AILERON THERAPEUTICS INC
      摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

      专利号:US-11702652-B2
      优先权日:2005-12-01
      标题:Enzymatic encoding methods for efficient synthesis of large libraries

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