CAS: 269410-25-5; 2,6-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenol

上下游产品

CAS号2374-05-2 4-溴-2,6-二甲基苯酚 | CAS号25015-63-8 频那醇硼烷 | CAS号934826-20-7 (4-羟基-3,5-二甲基苯基)硼酸

📜4-溴-2,6-二甲基苯酚置于[{pd(μ-Cl){κ2-P,C-P(Ipr)2(oc6H3-2-Ph)}}2],Sodium Acetate体系中,用 二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 6.0H,反应生成2,6-二甲基-4-(4,4,5,5-四甲基-1,3,2-二氧硼烷-2-yl)苯酚
参考文献:Bedford-Type Palladacycle-Catalyzed Miyaura Borylation Of Aryl Halides With Tetrahydroxydiboron In Water
标题:Bedford-Type Palladacycle-Catalyzed Miyaura Borylation Of Aryl Halides With Tetrahydroxydiboron In Water
摘要:A Mild Aqueous Protocol For Palladium Catalyzed Miyaura Borylation Of Aryl Iodides,Aryl Bromides And Aryl Chlorides With Tetrahydroxydiboron (Bba) As A Borylating Agent Is Developed. The Developed Methodology Requires Low Catalyst Loading Of Bedford-Type Palladacycle Catalyst (0.05 Mol %) And Works Best Under Mild Reaction Conditions At 40 Degrees C In Short Time Of 6 H In Water. In Addition,Our Studies Show That For Miyaura Borylation Using Bba In Aqueous Condition,Maintaining A Neutral Reaction Ph Is Very Important For Reproducibility And Higher Yields Of Corresponding Borylated Products. Moreover,Our Protocol Is Applicable For A Broad Range Of Aryl Halides,Corresponding Borylated Products Are Obtained In Excellent Yields Up To 93% With 29 Examples Demonstrating Its Broad Utility And Functional Group Tolerance.
Doi:10.1021/acs.Joc.7B02771

专利信息

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.