CAS: 2568-34-5; 2-(N-Methylbenzamido)Acetic Acid

该化合物是一种该化合物是一种独特的N-甲基-甲基-甲基-1-苯丙胺混合物,与乙酸组有关,这种结构使乙酸组成为合成有机化学中有价值的中间体,特别是用于准备氨化衍生物和催化剂.它的活性碳化物组可以进一步功能化,而N-甲基苯基替代品则会增强消毒和电子特性,影响对混合反应的回动.该化合物在药物研究中有用,可以作为生物活性分子的构件.高纯度能确保要求应用的一贯性.建议,在受控制条件下进行适当处理,因为其可能对湿度和热度敏感.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

sarcosine benzoyl chloride benzoic acid anhydridetrans-cinnamic acidα-(benzoyl-methyl-amino)-trans-cinnamic acid α-(benzoyl-methyl-amino)-cinnamic acid 6-(4-chloro-benzoyl)-7-methyl-1-phenyl-2-oxa-6,7-diaza-bicyclo[2.2.1]heptane-3,5-dione (+/-)-O-N-Methyl-hippuryl-2-hydroxy-buttersaeure

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氢氧化钾体系中,化学反应生成N-甲基马尿酸
    参考文献:Cook; Heilbron,Chemistry Of Penicillin
    标题:Cook; Heilbron,Chemistry Of Penicillin

    海关参考信息

    专利信息


    专利号:US-4710583-A
    优先权日:1985-10-21
    标 题:Dipeptides and process
    发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.

    专利号:US-4810817-A
    优先权日:1985-10-21
    标题 :Aspartyl-beta substituted phenylalanine dipeptides
    发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

    专利号:US-4873359-A
    优先权日:1985-10-21
    标题:Process for preparing as partyl-phenylalanine dipeptides
    发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L
    权利人:GRACE W R & CO
    摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.

    专利号:US-4494547-A
    优先权日:1981-03-30
    标 题 :2H-isoindolediones, their synthesis and use as radiosensitizers
    发明人:MYERS JOHN A
    权利人:UNIV NORTH CAROLINA
    摘要:Isoindoledione compounds of the formula: ##STR1## wherein: R 1 and R 3 each separately is phenyl, substituted phenyl, alkyl of 1 to 4 carbons, --CHO, --CH 2 OR 6 , --CO 2 R 6 , --COR 6 , hydrogen, or together with R 2 is a divalent alkyl or alkenyl group of 3 to 5 carbons which form a cyclic ring; n R 2 is phenyl, substituted phenyl, --CH 2 OR 6 , --CH 2 CH 2 OR 6 , alkyl of 1 to 4 carbons or with either R 1 or R 3 is a divalent alkyl or alkenyl group of 3 to 5 carbons which form a cyclic ring; n R 4 and R 5 which may be the same or different each separately is hydrogen, alkyl of 1 to 4 carbons, --OR 6 , --CO 2 R 6 , --COR 6 , --CHO, --CH 2 OR 6 or together R 4 and R 5 is a butadiene radical which forms a benzene ring; n R 6 is hydrogen or alkyl of 1 to 4 carbons; provided that R 1 and R 3 are not both phenyl and that when R 4 and R 5 are both hydrogen, R 1 , R 2 and R 3 are not all methyl. The compounds are useful as radio-sensitizers in the therapeutic radiation of cancerous tissues.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 245.
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