📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氢氧化钾体系中,化学反应生成N-甲基马尿酸 参考文献:Cook; Heilbron,Chemistry Of Penicillin 标题:Cook; Heilbron,Chemistry Of Penicillin
专利号:US-4710583-A 优先权日:1985-10-21 标 题:Dipeptides and process 发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L 权利人:GRACE W R & CO 摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspertame or derivative by enzymatic coupling of phenylserine or derivative with aspertic acid or derivative. Hydrogenation of the coupled product to give as final product aspertame or analog with related processes and products.
专利号:US-4810817-A 优先权日:1985-10-21 标题 :Aspartyl-beta substituted phenylalanine dipeptides 发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L 权利人:GRACE W R & CO 摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.
专利号:US-4873359-A 优先权日:1985-10-21 标题:Process for preparing as partyl-phenylalanine dipeptides 发明人:CHMURNY ALAN B; GROSS AKIVA T; KUPPER ROBERT J; ROBERTS ROWENA L 权利人:GRACE W R & CO 摘要:Synthesis of phenylserine ester (a) via benzaldehyde and glycine ester using serine hydroxymethyltransferase; and (b) via methyl benzoylacetate. Synthesis of hydroxy-aspartame or derivative by enzymatic coupling of phenylserine or derivative with aspartic acid or derivative. Hydrogenation of the coupled product to give as final product aspartame or analog with related processes and products.
专利号:US-4494547-A 优先权日:1981-03-30 标 题 :2H-isoindolediones, their synthesis and use as radiosensitizers 发明人:MYERS JOHN A 权利人:UNIV NORTH CAROLINA 摘要:Isoindoledione compounds of the formula: ##STR1## wherein: R 1 and R 3 each separately is phenyl, substituted phenyl, alkyl of 1 to 4 carbons, --CHO, --CH 2 OR 6 , --CO 2 R 6 , --COR 6 , hydrogen, or together with R 2 is a divalent alkyl or alkenyl group of 3 to 5 carbons which form a cyclic ring; n R 2 is phenyl, substituted phenyl, --CH 2 OR 6 , --CH 2 CH 2 OR 6 , alkyl of 1 to 4 carbons or with either R 1 or R 3 is a divalent alkyl or alkenyl group of 3 to 5 carbons which form a cyclic ring; n R 4 and R 5 which may be the same or different each separately is hydrogen, alkyl of 1 to 4 carbons, --OR 6 , --CO 2 R 6 , --COR 6 , --CHO, --CH 2 OR 6 or together R 4 and R 5 is a butadiene radical which forms a benzene ring; n R 6 is hydrogen or alkyl of 1 to 4 carbons; provided that R 1 and R 3 are not both phenyl and that when R 4 and R 5 are both hydrogen, R 1 , R 2 and R 3 are not all methyl. The compounds are useful as radio-sensitizers in the therapeutic radiation of cancerous tissues.