CAS: 18494-87-6; Benzothiophene-3-Sulfonyl Chloride

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CAS号66225-23-8 potassium 3-thi...

📜Potassium 3-Thianaphthenesulfonate置于potassium Chloride,五氯化磷体系中,用 水 用作溶剂,化学反应 1.0H,反应生成1-苯并噻吩-3-磺酰氯
参考文献:Novel Indol Carboxylic Acid Bispyridyl Carboxamide Derivatives,Pharmaceutically Acceptable Salt Thereof,Preparation Method And Composition Containing The Same As An Active Ingredient
标题:Novel Indol Carboxylic Acid Bispyridyl Carboxamide Derivatives,Pharmaceutically Acceptable Salt Thereof,Preparation Method And Composition Containing The Same As An Active Ingredient
摘要:本公开涉及一种新的吲哚羧酸双吡啶羧酰胺衍生物,其制备方法,以及包含该衍生物作为活性成分的用于预防或治疗肥胖,泌尿系统疾病和中枢神经系统疾病的组合物.根据本发明的吲哚羧酸双吡啶羧酰胺衍生物具有高亲和力5-Ht2C受体,对5-Ht2C受体选择性作用,这些衍生物很少出现由其他受体引起的不良反应.由于这些衍生物有效抑制5-羟色胺活性,它们可能对治疗或预防肥胖;泌尿系统疾病,如尿失禁,早泄,勃起功能障碍和前列腺增生;以及与5-Ht2C受体相关的中枢神经系统疾病,如抑郁症,焦虑症,关注症,恐慌症,癫痫,强迫症,偏头痛,睡眠障碍,戒毒,阿尔茨海默病和精神分裂症可能有用.

专利信息

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.