CAS: 1623-92-3; 4-Phenoxybenzene-1-Sulfonyl Chloride

上下游产品

CAS号20241-57-0 4-phenoxybenzen... | CAS号79-37-8 草酰氯 | CAS号101-84-8 二苯醚 | CAS号101-55-3 4-溴联苯醚 | CAS号83863-63-2 二苯并呋喃-水合-2-二磺酸 | CAS号38778-05-1 4-苯氧基苯硫酚 | CAS号294661-61-3 N-[(4-Phenoxyph... | CAS号106-46-7 1,4-二氯苯 | CAS号108-90-7 氯苯 | CAS号123045-62-5 4-苯氧基苯磺酰胺

📜二苯醚置于氯磺酸,氯化亚砜体系中,用 二氯甲烷 用作溶剂,化学反应 7.0H,以89%的收率获得4-苯氧基苯磺酰氯
参考文献:新型具有一氧化氮释放活性的新型基于苯并呋喃的吡咯烷异羟肟酸酯的合成及生物学评价
标题:新型具有一氧化氮释放活性的新型基于苯并呋喃的吡咯烷异羟肟酸酯的合成及生物学评价
摘要:在"多功能药物"策略的基础上,设计,合成和评估了一系列新型的以苯并呋喃聚糖骨架为一氧化氮供体的基质金属蛋白酶抑制剂(mmpi).所有合成的化合物,尤其是16A,均显示出有效的mmp-2,9抑制活性,抗增殖活性,并可能在hela细胞中产生高水平的no.还评估了它们的抗侵袭和抗血管生成作用.此外,与ly52相比,16A在体内表现出竞争性抗肿瘤活性.这些杂合的no-Mmpi可能会提供合适的支架,以开发有价值的mmp抑制剂,以进一步发现新型抗癌药物.
Doi:10.1016/j.Bmc.2018.06.023

专利信息

专利号:WO-2004020401-A1
优先权日:2002-09-02
标题 :Synthesis of sulfonamide derivatives
发明人：KALLIKAT JOHN; MANDAL ASHIS BARAN; GANESH SAMBASIVAM
权利人:SYNGENE INTERNAT PRIVATE LTD; KALLIKAT JOHN; MANDAL ASHIS BARAN; GANESH SAMBASIVAM
摘要:The novel method of synthesis of sulphonamide derivatives (I), comprising reaction of alkyl-4-halophenylsulfonate with an amine. Formula (I) wherein X is halogen and R1 and R2 are independently selected from group comprising (i) C1 to C15 alkyl, straight or branched, (ii) C3 to C15 cycloalkyl, substituted or unsubstituted, (iii) C2 to C15 alkenyl, straight or branched, (iv) C2 to C15 alkynyl, straight or branched, (v) phenyl or benzyl, substituted or unsubstituted, (vi) heterocycloalkyl, substituted or unsubstituted, (vii) hydrogen, (viii) form with the nitrogen to which they are attached a 3-7 membered heterocyclic moiety such as pyrolidine, piperidine, piperazine, imidazole, pyrazole, (ix) the alkyl in i) may be attached to a moiety selected from cycloalkyl or heterocycloalkyl, substituted or unsubstituted

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-8163773-B2
优先权日:2005-07-11
标题 :Organic compounds
发明人：BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

专利号:WO-2010039911-A1
优先权日:2008-10-01
标题 :Calcilytic compounds
发明人：JEONG JAE U; MARQUIS ROBERT W JR
权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.