专利号:US-12351573-B2 优先权日:2019-05-09 标 题:Compounds for use in synthesis of peptidomimetics 发明人:AL-ABED YOUSEF; CHENG KAI FAN 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
专利号:US-2023159450-A1 优先权日:2020-05-08 标 题 :Dimers for use in synthesis of peptidomimetics 发明人:AL-ABED YOUSEF; ALTITI AHMAD 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.
专利号:EP-1960423-B1 优先权日:2004-12-30 标 题:Synthesis of peptide t-20 using peptide intermediate fragments 发明人:HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N 权利人:HOFFMANN LA ROCHE 摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.
专利号:WO-2024261319-A1 优先权日:2023-06-23 标题 :Methods of chemical synthesis of peptides 发明人:AL MUSAIMI OTHMAN; WILLIAMS DARYL ROBERT 权利人:IMPERIAL COLLEGE INNOVATIONS LTD 摘要:The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.
专利号:EP-1833843-B1 优先权日:2004-12-30 标 题:Synthesis of peptide t-20 using peptide intermediate fragments 发明人:HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N 权利人:HOFFMANN LA ROCHE 摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.
专利号:US-2010261876-A1 优先权日:2007-09-25 标 题:Novel methods of synthesis for therapeutic antiviral peptides 发明人:BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E 权利人:BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E 摘要:Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.
参考文献:10.1371/journal.pone.0021350 摘要:Zhuang K, Finzi A, Tasca S, Shakirzyanova M, Knight H, Westmoreland S, Sodroski J, Cheng-Mayer C. Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques. PLoS ONE. 2011 Jul 08;6(7):e21350. doi: 10.1371/journal.pone.0021350. 参考文献:10.1371/journal.pone.0021535 摘要:Baatz F, Nijhuis M, Lemaire M, Riedijk M, Wensing AMJ, Servais J, van Ham PM, Hoepelman AIM, Koopmans PP, Sprenger HG, Devaux C, Schmit J, Perez Bercoff D. Impact of the HIV-1 env Genetic Context outside HR1–HR2 on Resistance to the Fusion Inhibitor Enfuvirtide and Viral Infectivity in Clinical Isolates. PLoS ONE. 2011 Jul 08;6(7):e21535. doi: 10.1371/journal.pone.0021535. 参考文献:10.1016/j.bbamem.2011.06.020 摘要:Ashkenazi A, Wexler-Cohen Y, Shai Y. Multifaceted action of Fuzeon as virus–cell membrane fusion inhibitor. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2011 Oct;1808(10):2352–8. doi: 10.1016/j.bbamem.2011.06.020.