CAS: 14757-78-9; 3-Bromofuran-2-Carbaldehyde

相似化合物

14903-90-3 59862-77-0 32460-07-4

📜3-溴呋喃 以 N,N-二甲基甲酰胺 用作溶剂,以14.22 G (81%)的收率获得3-硼-2-甲酸基呋喃
参考文献:Azabicyclic-Substituted Fused-Heteroaryl Compounds For The Treatment Of Disease
标题:Azabicyclic-Substituted Fused-Heteroaryl Compounds For The Treatment Of Disease
摘要:该发明提供了formula I中的化合物:1其中azabicyclo为23这些化合物可以是药用盐或组合物的形式,或者是它们的外消旋混合物或纯对映体.Formula I中的化合物在已知涉及α7的药物中是有用的.

专利信息

专利号:US-11584752-B2
优先权日:2020-09-08
标题 :Method for controlled release using mechanical force
发明人：ROBB MAXWELL J; HU XIAORAN; ZENG TIAN
权利人:CALIFORNIA INST OF TECHN
摘要:A general and modular mechanophore platform that efficiently releases a cargo molecule via a mechanically triggered cascade reaction is described, along with methods of synthesis and use thereof. The mechanophore platform comprises a stable Diels-Alder adduct mechanophore comprising a 2-furylcarbinol derivative as its diene component, wherein the 2-furylcarbinol derivative is, in turn, pre-loaded with a covalently attached cargo molecule, and wherein the Diels-Alder adduct mechanophore is embedded into a polymer chain or polymer network, such that the mechanophore platform undergoes the retro [4+2] cycloaddition reaction under mechanical force to reveal the unstable 2-furylcarbinol derivative, which, in turn, easily decomposes under mild conditions to release its molecule cargo.