CAS: 1354621-59-2; (3S,4S)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine
该化合物是一种三四点有固定立体化学的手淫媒衍生物,在3和4个位置上,使它成为制药和有机合成的宝贵中间体,其硬性双环结构和苯基替代品增强了其在不对称合成和药用化学应用中的效用.该化合物的高立体化学纯度确保了持续的再活动性,特别是在生物活性分子的开发中.其地雷功能允许进一步衍生,从而能够建造复杂的脚架.该化合物对于研究人员来说特别有利,因为研究人员在结壳,催化剂或药物候选者的合成过程中需要精确的立体控制.建议由于敏感性,在惰性条件下进行适当的处理.
- 英文名称(3S,4S)-1-Benzyl-N,4-Dimethylpiperidin-3-Amine
- 中文名称(3S,4S)-1-苄基-N,4-二甲基哌啶-3-胺
- IUPAC名称(3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine
- 其它别名托法替尼/托法替布杂质34; (3S,4S)-1-苯甲基-N,4-二甲基哌啶-3-胺; Tropsch Impurity
- CAS编号1354621-59-2
- MFCD编号:MFCD09878607
- EINECS号:110-809-1
- FDA UNII编号:4X53PX993G
- 分子式:C14H22N2分子量:218.34
- 产品CID: 550122
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
1354486-07-9 477600-68-3 477600-70-7物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamic acid methyl ester 1-benzyl-3-methoxycarbonylamino-4-methyl-pyridinium bromide tert-butyl (3R,4R)-1-benzyl-4-methylpiperidin-3-ylcarbamate benzylamine tert-butyl N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]carbamate 3-[(3R,4R)-3-[(6-aminopyrimidin-4-yl)(methyl)amino]-4-methylpiperidin-1-yl]-3-oxopropanenitrile tas°Citinib 4-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N4-methyl-2,3,4-pyridinetriamineN4-[(3R,4R)-1-benzyl-4-methyl-3-piperidinyl]-N4-methyl-2,3,4-pyridinetriamine合成工艺路线路线简述
- 32018-96-5 = 1354621-59-2 + 477600-70-7 + 1638499-31-6 + 1638499-33-8
反应条件:1.1 Reagents: Titanium Isopropoxide Solvents: Methanol; 0 - 15 °C; 1 H,5 - 15 °C1.2 Reagents: Sodium Borohydride; 1 H,5 - 15 °C
标题:An Improved And Efficient Process For The Preparation Of Tofacitinib Citrate
作者:Patil,Yogesh S.; Bonde,Nilesh L.; Kekan,Ankush S.; Sathe,Dhananjay G.; Das,Arijit
参考文献:Organic Process Research & Development 日期:2014 卷标:18(12) 页码:1714-1720
📜Methyl ((3S,4S)-1-Benzyl-4-Methylpiperidin-3-yl)Carbamate置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 2.58H,反应生成(3S,4S)-1-苄基-N,4-二甲基哌啶-3-胺
参考文献:Process For The Preparation Of Chiral 3-Amino-Piperidins,Useful Intermediates For The Preparation Of Tofacitinib
标题:Process For The Preparation Of Chiral 3-Amino-Piperidins,Useful Intermediates For The Preparation Of Tofacitinib
摘要:本发明的目的是提供一种改进的过程,通过手性铑催化剂制备(3R,4R)-1-苄基-4-甲基哌啶-3-胺.
海关参考信息
- 2902300000-甲苯
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8309716-B2
优先权日:2005-07-29
标题 :Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis
发明人：RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J
权利人:RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J; PFIZER
摘要:This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1055/s-0039-1690702
摘要:Chen Y, Du F, Chen F, Zhou Q, Chen G. Methyl-α-d-glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation. Synthesis. 2019 Oct 14;51(24):4590–600. doi: 10.1055/s-0039-1690702.
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