CAS: 130798-48-0; (R)-Di-2-Naphthylprolinol
该化合物是用于非对称合成的手性辅助剂和紧固剂,因为其具有要求性要求且电子含量高的结构.其硬性环烷基化合物在催化反应中,特别是在非对称添加和减少中,加强了对等选择性.该化合物的高度稳定性和可预测的协调行为使得它对于过渡-金属催化具有价值,例如在Rh-或Cu-催化变中.它的丙醇骨干进一步便利了氢-诱导互动,改善了基质控制. (R)-Di-2-Naphthylprol因其在产品中诱导高对等成体过剩的能力而得到青睐. 这使得它在制药和精美化学应用中为复杂的立体选择性合成物做出了可靠的选择.
物理性质
MSDS等安全信息
- 警示词Warning
- 危险描述H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] - 防范说明P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
- 危险品标志Xi
- 安全声明26-36-37/39
- 危险类别码36/37/38
- WGK Germany3
上下游产品
N-benzyl-(R)-(-)-2-(di-β-naphthylhydroxymethyl)pyrrolidine (D)-1-benzylpyrrolidine-2-carboxylic acid N-benzyl-(R)-(+)-proline methyl ester D-Prolin acrylic acid (S)-6-[4-[2-(hydroxydinaphthalen-2-ylmethyl)pyrrolidine-1-carbonyl]-phenoxy]hexyl ester (S)-2-(((methyldiphenylsilyl)oxy)di(naphthalen-2-yl)methyl)pyrrolidine合成工艺路线路线简述
📜D-脯氨酸置于palladium Dihydroxide,甲烷 Sodium Hydroxide,四丁基氢氧化铵,氢气,碘,Magnesium,溶剂黄146,乙酰氯,Potassium Iodide体系中,用 甲醇,水 用作溶剂,23.0~65.0 °C,101.33 Kpa 条件下,反应 68.5H,反应生成(R)-二-2-萘基脯氨醇
参考文献:A Catalytic Enantioselective Synthesis Of Denopamine,A Useful Drug For Congestive Heart Failure
标题:A Catalytic Enantioselective Synthesis Of Denopamine,A Useful Drug For Congestive Heart Failure
摘要:
Doi:10.1021/jo00001A084
海关参考信息
- 2902600000-乙苯
2902902000-精萘
2905121000-正丙醇
2905130000-正丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.
专利号:US-2002010339-A1
优先权日:1998-05-26
标 题:Method for synthesis of halopyridyl-acyclopentane derivative and intermediate thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考DOI号:10.1016/S0040-4039(01)93871-7
📝 需求与反馈
尽可能描述清楚需求与问题信息
