CAS: 1256565-36-2; 4-Chlorophenyl (S)-6-Chloro-1-(4-Methoxyphenyl)-1,3,4,9-Tetrahydro-2H-Pyrido[3,4-B]Indole-2-Carboxylate
- 英文名称4-Chlorophenyl (S)-6-Chloro-1-(4-Methoxyphenyl)-1,3,4,9-Tetrahydro-2H-Pyrido[3,4-B]Indole-2-Carboxylate
- 中文名称4-氯苯基(S)-6-氯-1-(4-甲氧基苯基)-1,3,4,9-四氢-2H-B[3,4-B]吲哚-2-羧酸甲酯
- IUPAC名称4-chlorophenyl (S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate
- CAS编号1256565-36-2
- MFCD编号:MFCD32067941
- 分子式:C25H20Cl2N2O3分子量:467.35
- 产品CID: 382280
- 产品分类Protein Tyrosine Kinase/RTK → VEGFR | Inhibitors/Agonists → Cell Cycle → DNA/RNA Synthesis | Inhibitors/Agonists → Cell Cycle → DNA/RNA Synthesis | Inhibitors/Agonists → Metabolic Enzyme → Dehydrogenase
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2905110000-甲醇
2908191000-对氯苯酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10947231-B2
优先权日:2009-05-27
标题:Processes for the preparation of substituted tetrahydro beta-carbolines
发明人：HWANG PETER SEONGWOO; MOON YOUNG-CHOON; TAMIL ARASU; QI HONGYAN; ALMSTEAD NEIL
权利人:PTC THERAPEUTICS INC
摘要:Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):
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主要参考文献
1: Yang K, Kong R, Spiegel R, Baird JD, O'Keefe K, Howell BA, Watkins PB. Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients. Clin Pharmacol Ther. 2024 Mar;115(3):525-534. doi: 10.1002/cpt.3136. Epub 2023 Dec 21. 52(1):DMD-AR-2023-001471. doi: 10.1124/dmd.123.001471. 79(8):1073-1080. doi: 10.1007/s00228-023-03513-4. Epub 2023 Jun 6.
4: Morton TL, Laskin OL, Kaushik D, Lee L, Ma J, Kristensen A, O'Keefe K, Golden L, Klein M, Kong R. A pharmacokinetic drug-drug interaction study between rosuvastatin and emvododstat, a potent anti-SARS-CoV-2 (COVID-19) DHODH (dihydroorotate dehydrogenase) inhibitor. Pharmacol Res Perspect. 2023 Apr;11(2):e01076. doi: 10.1002/prp2.1076.
5: Ma J, Ye Q, Northcutt V, Babiak J, Kong R. Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs. Xenobiotica. 2022 Dec;52(12):1031-1040. doi: 10.1080/00498254.2023.2171925. Epub 2023 Feb 3.
合成参考文献
参考文献:10.1016/j.ejmech.2022.114826
摘要:Baiazitov RY, Qi H, Arasu T, Lennox W, Cao L, Weetall M, Furia B, Zhuo J, Choi S, Kim MJ, Sheedy J, Davis T, Moon Y. SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor. European Journal of Medicinal Chemistry. 2022 Dec;244():114826. doi: 10.1016/j.ejmech.2022.114826.
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