CAS: 123-78-4; (2S,3R,E)-2-Aminooctadec-4-Ene-1,3-Diol

上下游产品

CAS号116467-63-1 (4E,2S,3R)-1,3-... | CAS号572922-39-5 2-phenyl-4-(S)-... | CAS号105308-75-6 (2'E,4S,1'R)-4-... | CAS号103348-49-8 (2S,3R,4E)-2-叠氮... | CAS号115464-03-4 tert-butyl (4S)... | CAS号1094213-80-5 (2S,3R)-(4E)-1-... | CAS号511542-07-7 (2S,3R,4E)-2-am... | CAS号10575-28-7 1-hydroxy°Ctade... | CAS号3102-57-6 N-乙酰基神经鞘氨醇 | CAS号123-78-4 D-鞘氨醇 | CAS号26993-30-6 D-苏式-鞘胺醇-1-磷酸 | CAS号544-63-8 肉豆蔻酸 | CAS号638-53-9 十三烷酸 | CAS号54164-50-0 C24:1 神经酰胺 (d18... | CAS号764-22-7 D-赤式-二氢鞘氨醇 | CAS号74713-60-3 N-月桂酰-D-鞘胺醇 | CAS号74713-59-0 N-辛酰基-D-神经鞘氨醇

📜N-乙酰基神经鞘氨醇置于一水合肼体系中,化学反应 20.0H,以60%的收率获得d-鞘氨醇
参考文献:Sphingolipids And Glycerolipids. Part Ii. Syntheses Of Two Pairs Of Enantiomeric C18-Sphingosines And A Palmitoyl Analogue Of Gaucher Spleen Glucocerebroside.
标题:Sphingolipids And Glycerolipids. Part Ii. Syntheses Of Two Pairs Of Enantiomeric C18-Sphingosines And A Palmitoyl Analogue Of Gaucher Spleen Glucocerebroside.
摘要:已合成十六种手性c4-环氧化物 [(-)-10A-D,(+)-10A-D,(-)-11A-D,(+)-11A-D],这些化合物是我们合成复杂脂质策略中的合成子,通过使用sharpless不对称环氧化反应,从(2Z)-2-丁烯-1,4-二醇(6)制备而成.利用手性c4-环氧化物 [(+)-10A,(-)-10A,(-)-11A,(+)-11A] 作为起始化合物,通过环氧环的区域选择性开环反应与叠氮阴离子结合,随后将叠氮基团还原为氨基,并进行wittig反应,合成了两对对映异构体(d-赤藓糖,L-赤藓糖,D-反式,L-反式)c18-鞘氨醇(1,2,3,4).此外,D-赤藓糖-C18-鞘氨醇(1)通过与棕榈酸和d-葡萄糖的连续缩合反应途径转化为高雪氏脾脏葡萄糖苷脂(5)的棕榈酰类似物(5A).
Doi:10.1248/cpb.40.1154

专利信息

专利号:US-2024110196-A1
优先权日:2022-08-29
标题 :Use of multigene stacking method in synthesis of nervonic acid in brassica napus
发明人：LIU FANG; WANG PANDI; WU GANG; XIONG XIAOJUAN
权利人:OIL CROPS RES INSTITUTE CAAS
摘要:The present disclosure relates to use of a multigene stacking method in synthesis of nervonic acid in Brassica napus. The present disclosure provides a multigene co-expression plant vector, including an initial backbone of pBWA(V)BII and multiple exogenous gene expression cassettes. The present disclosure further provides two plant vectors applicable to genetic transformation, including a three-gene co-expression plant vector and a five-gene co-expression plant vector. In the present disclosure, after the three-gene co-expression plant vector and the five-gene co-expression plant vector are separately transferred into the Brassica napus, the nervonic acid (NA) with a high content is synthesized in the Brassica napus through multigene co-expression. An NA ratio can be significantly increased combined with a higher seed oil content and a greater field seed yield. The plant vector realizes efficient synthesis of NA in oil crops, obtains NA-rich seed oil, and increases an added value of edible oil.

专利号:US-6440703-B1
优先权日:1997-12-01
标 题 :Enzymatic synthesis of gangliosides
发明人：DEFREES SHAWN
权利人:NEOSE TECHNOLOGIES INC
摘要:This invention provides methods for practical in vitro synthesis of gangliosides and other glycolipids. The synthetic methods typically involve enzymatic synthesis, or a combination of enzymatic and chemical synthesis. One or more of the enzymatic steps is preferably carried out in the presence of an organic solvent.

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-2006211083-A1
优先权日:2005-01-21
标题:Products and processes for in vitro synthesis of biomolecules
发明人：KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.