CAS: 97004-04-1; (6-Chloropyridin-3-yl)Methanamine

• 英文名称(6-Chloropyridin-3-yl)Methanamine
• 中文名称5-氨基甲基-2-氯吡啶
• IUPAC名称(6-chloropyridin-3-yl)methanamine
• 其它别名5-(氨基甲基)-2-氯吡啶; 6-Chloro-3-Picolylamine
• CAS编号97004-04-1
• MFCD编号:MFCD00673153
• EINECS号:619-497-6
• 分子式:C6H7ClN2
• 分子量:142.59
• 产品CID: 2019704
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: XPARFBOWIYMLMY-UHFFFAOYSA-N
• InChI=1S/C6H7ClN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2…
• 计算化学: 氢键受体数2.0氢键供体数1可旋转键数1

相似化合物

物理性质

• 熔点28-34°C
• 沸点101-102 °C at 1 mmHg
• 闪点107.6±23.2 °C
• 密度1.2±0.1 g/cm3
• pKa:7.78±0.29(预测)
• PSA:38.91
• LogP:1.1937
• 折射率1.572
• 蒸汽压0.0±0.5 mmHg at 25°C
• 溶解性Chloroform (Slightly), Methanol (Slightly)
• 敏感性吸潮
• 外观形态类白色至浅棕色油状物至低熔点固体
• 储存条件在惰性气体(氮气或氩气)下 2–8 °C
• 产品应用该化合物用于合成具有FAAH(脂肪酸氨化氢解盐)抑制作用的和模拟物.

MSDS等安全信息

• GHS象形图
• GHS符号GHS06 & GHS05;
  注释: Skull and crossbones & Corrosion
• 危险类别急性毒性 类别3(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  皮肤致敏 类别1
  皮肤腐蚀 类别1C
• 警示词Danger(危险)
• 危险描述H301 |吞咽会中毒.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H317 |可能引起皮肤过敏反应.
  H314 |造成严重皮肤灼伤和眼损伤.
• 防范说明P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级6.1
• UN编号2811.0
• 危险品标志T,C
• 包装等级Ⅲ
• 安全声明26-36/37/39-45-20
• 危险类别码25-37/38-41-43-34
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 139650-35-4 = 97004-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 1 H,61 °C; 14 H,50 °C
  标题:Synthesis Of Arylmethyl Amine By Hexamethylenetetramine
  作者:Jia,Huai-Feng; Wang,Kai-Ming; Wang,Da-Wei; Zhao,Bao-Xiang
  参考文献:Hecheng Huaxue 日期:2005 卷标:13(6) 页码:630-631]
  
  139650-35-4 = 97004-04-1
  反应条件:1.1 Reagents: Methanol,Hydrochloric Acid Solvents: Water
  标题:Preparation Of 2-Chloro-5-Methylpyridines
  参考文献:Japan]
  
  153469-10-4 + 16722-51-3 = 97004-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water
  标题:Preparation Of 2-Chloro-5-(Aminomethyl)Pyridine And Its Intermediates
  参考文献:Japan]
  
  1080018-12-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 6 H,75 - 80 °C1.2 Reagents: Sodium Hydroxide Solvents: Chloroform,Water; Basified
  标题:Preparation Of N-Methylidene-Substituted Methylamine Polymers
  参考文献:Japan]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Solvents: Methanol; 12 H,Rt
  标题:Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism And Epigenetics: Discovery Of Novel Nicotinamide Phosphoribosyltransferase (Nampt) And Histone Deacetylase (Hdac) Dual Inhibitors
  作者:Dong,Guoqiang; Chen,Wei; Wang,Xia; Yang,Xinglin; Xu,Tianying; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(19) 页码:7965-7983]
  
  120739-60-8 = 97004-04-1
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Preparation Of Chlorine-Containing Heterocyclic Group-Substituted Methylamines
  参考文献:Japan]
  
  18368-64-4 = 97004-04-1
  反应条件:1.1 Reagents: Potassium Carbonate; 3 H,120 °C1.2 Reagents: Potassium Hydroxide Solvents: Water
  标题:The New Synthesis Technique For 2-Chloro-5-(Aminomethyl)Pyridine
  作者:Lu,Zhaoping; Yang,Hong; Luo,Jinxiang
  参考文献:Nongyao 日期:2005 卷标:44(10)]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonium Hydroxide Catalysts: Aluminum Alloy,Base,Al 62,Ni 38 Solvents: Water
  标题:Highly Selective Hydrogenation Of 2-Chloro-5-Cyanopyridine With An Improved Sponge Nickel Catalyst
  作者:Tanaka,Ken; Nagasawa,Minoru; Kasuga,Yuzo; Sakamura,Hideki; Takuma,Yuki; Et Al
  参考文献:Tetrahedron Letters 日期:1999 卷标:40(32) 页码:5885-5888]
  
  120739-60-8 = 97004-04-1
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water1.3 Reagents: Sodium Hydroxide Solvents: Water
  标题:Synthesis Of Pesticide Intermediate 2-Chloro-5-Aminomethylpyridine
  作者:Jin,Jianping; Chen,Hukui
  参考文献:Shanghai Huagong 日期:2000 卷标:25(22) 页码:15-18]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Cobalt Solvents: Toluene,Ammonia
  标题:Preparation Of 5-(Aminomethyl)-2-Chloropyridine From 2-Chloro-5-Cyanopyridine
  参考文献:Germany]
  
  185379-79-7 = 97004-04-1
  反应条件:1.1 Reagents: Methanol Catalysts: Hydrochloric Acid Solvents: Toluene,Water1.2 Reagents: Sodium Hydroxide Solvents: Water
  标题:Method For Producing N-Methylidene-2-Chloro-5-Pyridinemethaneamine
  参考文献:Japan]
  
  1080018-12-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 6 H,75 - 80 °C
  标题:Process For Producing Substituted Methylamine Compound And Triazine Derivative
  参考文献:World Intellectual Property Organization]
  
  120739-60-8 = 97004-04-1
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; Rt; 5 H,Reflux; Cooled
  标题:Synthesis,Herbicidal Activities,And 3D-Qsar Of 2-Cyanoacrylates Containing Aromatic Methylamine Moieties
  作者:Liu,Yu-Xiu; Wei,Deng-Guo; Zhu,Ye-Rong; Liu,Shao-Hua; Zhang,Yong-Lin; Et Al
  参考文献:Journal Of Agricultural And Food Chemistry 日期:2008 卷标:56(1) 页码:204-212]
  
  139650-35-4 = 97004-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water
  标题:Preparation Of 2-Chloro-5-(Aminomethyl)Pyridine,2-Chloro-5-Pyridylmethylhexamethylenetetraammonium Chloride,And Its Preparation
  参考文献:Japan]
  
  70258-18-3 = 97004-04-1
  反应条件:1.1 Reagents: Hexamethylenetetramine Solvents: Acetonitrile; Rt -> Reflux1.2 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 2 H,61 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 9
  标题:Synthesis Of 2-Chloro-5-(Aminomethyl)Pyridine
  作者:Wang,Qi; Xiao,Guomin
  参考文献:Huagong Shikan 日期:2006 卷标:20(3) 页码:51-53]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol
  标题:Method For Producing α-Halo(Aminomethyl)Pyridine Derivative By Reduction Of α-Halocyanopyridine
  参考文献:Japan]
  
  151837-57-9 = 97004-04-1
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water
  标题:Heterocycle-Substituted Formamide Derivatives And Their Preparation
  参考文献:Japan]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonia,Sodium Sulfate Catalysts: Nickel Solvents: Ethanol
  标题:Preparation Of Halo(Aminomethyl)Pyridines
  参考文献:Japan]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Solvents: Ethanol,Water
  标题:Practical Synthesis Of (6-Chloro-3-Pyridyl)Methylamine By Highly Selective Hydrogenation Of 6-Chloro-3-Pyridinecarbonitrile With Improved Raney Nickel Catalyst
  作者:Tanaka,Ken; Nagasawa,Minoru; Sakamura,Hideki
  参考文献:Bulletin Of The Chemical Society Of Japan 日期:2000 卷标:73(5) 页码:1227-1231]
  
  33252-28-7 = 97004-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Alloy,Base,Ni 94,Al 6.3 Solvents: Water
  标题:Preparation Of Halogen-Containing Aromatic Aminomethyl Compounds
  参考文献:Japan

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管