CAS: 952412-99-6; (R)-2-(1-Hydroxybutyl)Benzoic Acid
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3-propyl-3H-isobenzofuran-1-one合成工艺路线路线简述
📜3-Hydroxy-3-Propyl-3H-Isobenzofuran-1-One置于sodium Hydroxide,Sodium Tetrahydroborate体系中,化学反应 1.0H,反应生成 丁苯酞杂质43
参考文献:Synthesis,Resolution,And Antiplatelet Activity Of 3-Substituted 1(3H)-Isobenzofuranone
标题:Synthesis,Resolution,And Antiplatelet Activity Of 3-Substituted 1(3H)-Isobenzofuranone
摘要:A Series Of 3-Substituted-1(3H)-Isobenzofuranone 6A-G And 7A-G Were Synthesized From Phthalic Anhydride. The Compound 6A-G Was Resolved. The Antiplatelet Activities Of These Compounds Were Evaluated Using In Vitro Experiment Of Platelet Aggregation. The Levels Of Antiplatelet Activity Were Displayed As Following Sequence: L-Isomer > Dl-Isomer > D-Isomer,Respectively. The Alkylphthalide Is More Active Than The Corresponding Alkenephthalide. All These Compounds Were Less Active Than N-Butylphthalide (Nbp,6C) And Aspirin (Asp). (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2007.06.082
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2905121000-正丙醇
2905130000-正丁醇
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合成参考文献
合成方法参考DOI号:10.1016/j.bmcl.2007.06.082
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