CAS: 847225-56-3; 4-Fluoropicolinonitrile

相似化合物

1060809-18-8 886371-78-4 327056-62-2

4-氯吡啶-2-甲酸甲酯置于ammonium Hydroxide,氯化亚砜,四乙基溴化铵,四苯基溴化膦,Cesium Fluoride体系中,用 N-甲基吡咯烷酮,甲醇,二氯甲烷 作为反应溶剂,化学反应生成 4-氟吡啶-2-甲腈
参考文献:一种2-氰基-4-氟吡啶的制备方法
标题:一种2-氰基-4-氟吡啶的制备方法
摘要:本发明公开了一种2‑氰基‑4‑氟吡啶的制备方法,该方法以4‑氯吡啶‑2‑甲酸甲酯为原料,经酯的氨解反应,酰胺脱水反应,卤素交换反应制备2‑氰基‑4‑氟吡啶.该方法合成工艺简单,反应条件温和,收率高,产品纯度好;所用原料易得,成本低,适合工业化生产.

专利信息

专利号:EP-1875239-B1
优先权日:2005-04-27
标题 :A method for the preparation of imaging probes using click chemistry
发明人：KOLB HARTMUTH C; MOCHARLA VANI P; WALSH JOSEPH C
权利人:SIEMENS MEDICAL SOLUTIONS
摘要:The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.