CAS: 76575-71-8; Methyl 3-Amino-5-Methylthiophene-2-Carboxylate

该化合物是一种多用途的热循环化合物,在3位置用硫苯核心替换氨基,在2位置用甲基酯替换.这一结构使它在有机合成中成为有价值的中间体,特别是在制药,农用化学品和功能材料的准备方面.氨基和酯功能的存在可以进一步衍生,从而能够建造更复杂的分子结构.在标准条件下和与一系列反应条件的兼容性增强了其在多步骤合成路线上的效用.该化合物通常供应高纯度,确保研究和工业应用的可靠性能.

英文名称Methyl 3-Amino-5-Methylthiophene-2-Carboxylate
中文名称3-氨基-5-甲基噻吩-2-羧酸甲酯
IUPAC名称methyl 3-amino-5-methylthiophene-2-carboxylate
其它别名2-氨基-5-甲基噻吩-2-羧酸甲酯; Methyl 3-Amino-5-Methylthiophen-2-Carboxylate
CAS编号76575-71-8
MFCD编号:MFCD00130095
EINECS号:814-593-6
分子式:C7H9NO2S
分子量:171.22
产品CID: 1757924
产品分类有机原料→分子砌块→芳杂环类化合物→噻吩类化合物

相似结构搜索
InChIKey: FVKMOPIFLCMZMI-UHFFFAOYSA-N
InChI=1S/C7H9NO2S/c1-4-3-5(8)6(11-4)7(9)10-2/h3H,8H2,1-2H3…
计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

欧盟法规

C&L通报

上下游产品

CAS号4786-20-3 2-丁烯腈 | CAS号2365-48-2 巯基乙酸甲酯 | CAS号35265-80-6 2,4-二羟基-6-甲基-噻吩... | CAS号1257535-60-6 3-溴-5-甲基噻吩-2-羧酸甲酯

合成工艺路线路线简述

合成目标产物 Methyl 3-Amino-5-Methylthiophene-2-Carboxylate 主要起始原料 Crotononitrile (Pract) And Methyl Thioglycolate
(文献来源)合成步骤主要原料 Crotononitrile (Pract) 和 Methyl Thioglycolate

3-溴-5-甲基噻吩-2-羧酸甲酯置于copper(I) Oxide,氨体系中,用 1,4-二氧六环,水作为反应溶剂,以68 %的收率获得产物3-氨基-5-甲基噻吩-2-羧酸甲酯
参考文献:Cn116023359
标题:Cn116023359

海关参考信息

2912110000-甲醛
2915110000-甲酸
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4670560-A
优先权日:1986-04-28
标题:Thienopyrimidine-2,4-dione derivatives and intermediates thereof
发明人：PRESS JEFFERY B; RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are generally vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.

专利号:US-4707550-A
优先权日:1986-04-28
标题 :N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas
发明人：PRESS JEFFERY B; RUSSELL RONALD K
权利人:ORTHO PHARMA CORP
摘要:The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.

专利号:CN-116023359-B
优先权日:2022-12-29
标题:A kind of synthesis method of aminothiophene compound and aminothiophene compound

专利号:CN-116023359-A
优先权日:2022-12-29
标题 :Synthesis method of aminothiophene compound and aminothiophene compound