CAS: 61941-79-5; 2-Hydroxy-5-Methoxypyridine

相似化合物

1052722-33-4 5154-01-8 1630197-34-0

上下游产品

CAS号10167-97-2 2-氨基-5-甲氧基吡啶 | CAS号1072-97-5 2-氨基-5-溴吡啶

📜2-溴-5-甲氧基吡啶置于苯甲醛肟,N1,N2-双(2-噻吩甲基)-乙二酰胺,Caesium Carbonate,Copper(L) Chloride体系中,用 二甲基亚砜 作为反应溶剂,化学反应 20.0H,以64%的收率获得产物5-甲氧基-(9CI)2(1H)-吡啶酮
参考文献:从药物化合物库中鉴定铜催化的c-O偶联的草酰胺配体
标题:从药物化合物库中鉴定铜催化的c-O偶联的草酰胺配体
摘要:一个典型的药物化合物库具有分子多样性,可以为发现新的配体结构提供平台.本文中,我们描述了这种方法与高通量筛选的结合使用,以鉴定n,N'-双(噻吩-2-基甲基)草酰胺为配体,通常对铜催化的c-O交叉偶联有效.在温和的条件下都可以同时使用联芳醚和苯酚.
DOI:10.1002/cctc.201900393

专利信息

专利号:WO-2025030970-A1
优先权日:2023-08-04
标 题:Condensing agent and use thereof in preparation of isothiocyanate
发明人：SI XIAOJIA; CHEN QUAN; LEI AIWEN; YI HONG; CHEN YI-HUNG
权利人:HUAWEI TECH CO LTD
摘要:The present application relates to the field of organic synthesis. Provided is a condensing agent. The condensing agent has formula 1, wherein R1 and R2 are each independently selected from the same or different electron-withdrawing groups. Compared with thiophosgene or carbon disulfide used in a traditional solution, the condensing agent provided in the embodiments of the present application has lower toxicity, and the condensing agent is a solid, such that the diffusion of pollution is easily controlled. Therefore, the condensing agent provided in the embodiments of the present application can be used for environmentally friendly synthesis of an isothiocyanate compound and has relatively small influence on the environment. Moreover, the condensing agent provided in the embodiments of the present application comprises electron-withdrawing groups, such that the yield of the isothiocyanate compound can be increased.

专利号:WO-2024159285-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting aryl pyridine compounds. More specifically, the present invention relates to aryl pyridines comprising formula (I): (I), in which the substituents R1 to R10 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related diseases.

专利号:WO-2024159288-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting amides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting amides. More specifically, the present invention relates to amides comprising formula (I): (Ia) (Ib), in which the substituents R1 to R27 are selected independently of the groups defined in the description, as well as to processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.