CAS: 53750-66-6; 4-Chloropicolinoyl Chloride

相似化合物

63071-13-6 137178-88-2 311767-65-4

上下游产品

CAS号5470-22-4 4-氯-2-吡啶甲酸 | CAS号98-98-6 2-吡啶甲酸 | CAS号59-67-6 烟酸 | CAS号35895-54-6 4-chloro-1-oxid... | CAS号14933-78-9 4-硝基吡啶-2-甲酸 1-氧化物 | CAS号1090815-16-9 N-Cyclopropyl 4... | CAS号1094332-66-7 N-Cyclohexyl 4-... | CAS号5470-22-4 4-氯-2-吡啶甲酸 | CAS号206193-53-5 4-chloro-3-iodo... | CAS号184304-16-3 2-Formyl-4-pyrr... | CAS号24484-96-6 2-氨基-5-硝基-4-氯吡啶 | CAS号99586-65-9 4-氯吡啶-2-甲酰胺 | CAS号24484-93-3 4-氯吡啶-2-甲酸甲酯 | CAS号71777-70-3 4-乙氧基-2-吡啶甲酸乙酯 | CAS号63071-10-3 4-氯-2-吡啶甲醇

2-吡啶甲酸置于氯化亚砜体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-氯-吡啶-2-酰氯
参考文献:索拉非尼-钌配合物的合成,生物活性研究及其在抗癌药物输送系统中的应用
标题:索拉非尼-钌配合物的合成,生物活性研究及其在抗癌药物输送系统中的应用
摘要:索拉非尼是一种多激酶抑制剂,广泛用作肝细胞癌的一线治疗.然而,当索拉非尼被证明不够时,需要更有效的替代品.在这项研究中,我们的目标是设计一种超越索拉非尼功效的结构,使我们首次合成索拉非尼-钌络合物并研究其特性.我们的结果表明,与单独的索拉非尼相比,索拉非尼-钌复合物表现出更好的表皮生长因子受体(egfr)抑制作用.有趣的是,在这些复合物中,Ru3S对各种癌细胞系(包括索拉非尼耐药 Hepg2 细胞)表现出高活性,同时在健康细胞系中表现出明显低于索拉非尼的细胞毒性.细胞周期,细胞凋亡和抗血管反应生成作用的进一步评估,分子对接和分子动力学研究表明,Ru3S作为候选药物具有巨大的潜力.此外,当游离ru3S被封装到聚合物胶束m1中时,观测到对hepg2细胞的细胞毒性增强.总的来说,这些发现使ru3S成为 Egfr 抑制的有前途的候选者,并值得为药物开发目的进行进一步探索.
DOI:10.1021/acs.Jmedchem.3C01115

专利信息

专利号:US-3933830-A
优先权日:1974-09-10
标 题 :Process for the synthesis of 4-(2-pyridylamido ethyl) piperidines
发明人：BARTH WAYNE E; KUHLA DONALD E
权利人:PFIZER
摘要:Disclosed herein is an improved process for the preparation of known hypoglycemic piperidinesulfamylureas of the structure ##EQU1## wherein R is selected from the group consisting of 3-(2-methoxy)pyridyl, 3-(2-ethoxy)pyridyl and 2-(4-chloro)pyridyl and R' is selected from the group consisting of bicyclo[2.2.1]hept-5-en-2-yl-endo-methyl, bicyclo[2.2.1]hept-2-yl-endo-methyl, 7-oxabicyclo[2.2.1]hept-2-yl-methyl, 1-adamantyl and cycloalkyl having from five to eight carbon atoms. n Said process comprises contacting 4-(2-pyridyl-amidoethyl) piperidine of the structure ##EQU2## with substantially one equivalent of sulfamide thereby exclusively sulfonating the piperidine nitrogen atom. Said 4-(2-pyridylamidoethyl)piperidines from the corresponding 4-(2-pyridylamidoethyl) pyridines by selectively activating the more basic nitrogen atom of said pyridine compound either by N-alkylation or by contact with acid and then exclusively reducing the activated pyridine ring with either hydrogen alone or in combination with a metal hydride. Said 4-(2-pyridylamidoethyl)pyridines are produced by contacting 4-(2-aminoethyl)pyridine with a pyridyl acid chloride of the formula R(C=O)Cl. The piperidine sulfonamides produced by the process of the instant invention are converted to the desired hypoglycemic agent by methods well-known to those skilled in the art. n The 4-(2-pyridylamidoethyl)pyridines and piperidines of the instant invention are themselves novel compounds useful as intermediates in the synthesis of piperidine sulfamylurea hypoglycemic agents.

专利号:WO-2024018354-A1
优先权日:2022-07-18
标题 :A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof
发明人：MAL SANJIB; SARKAR PARANTAP; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER GUENTHER MARIA
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).

专利号:US-3992388-A
优先权日:1974-09-10
标题 :4-(2-Pyridylamidoethyl)piperidines
发明人：BARTH WAYNE E; KUHLA DONALD E
权利人:PFIZER
摘要:Disclosed herein is an improved process for the preparation of known hypoglycemic piperidinesulfamylureas of the structue ##SPC1## n Wherein R is selected from the group consisting of 3-(2-methoxy)pyridyl, 3-(2-ethoxy)pyridyl and 2-(4-chloro)pyridyl and R' is selected from the group consisting of bicyclo[2.2.1]hept-5-en-2-yl-endo-methyl, bicyclo[2.2.1]hept-2-yl-endo-methyl, 7-oxabicyclo[2.2.1]hept-2-yl-methyl, 1-adamantyl and cycloalkyl having from five to eight carbon atoms. n Said process comprises contacting 4-(2-pyridyl-amidoethyl) piperidine of the structue ##SPC2## n With substantially one equivalent of sulfamide thereby exclusively sulfonating the piperidine nitrogen atom. Said 4-(2-pyridylamidoethyl)piperidines from the corresponding 4-(2-pyridylamidoethyl) pyridines by selectively activating the more basic nitrogen atom of said pyridine compound either by N-alkylation or by contact with acid and then exclusively reducing the activated pyridine ring with either hydrogen alone or in combination with a metal hydride. Said 4-(2-pyridylamidoethyl)pyridines are produced by contacting 4-(2-aminoethyl)pyridine with a pyridyl acid chloride of the formula R(C=O)Cl. The piperidine sulfonamides produced by the process of the instant invention are converted to the desired hypoglycemic agent by methods well-known to those skilled in the art. n The 4-(2-pyridylamidoethyl)pyridines and piperidines of the instant invention are themselves novel compounds useful as intermediates in the synthesis of piperidine sulfamylurea hypoglycemic agents.

专利号:TW-202404943-A
优先权日:2022-07-18
标题:A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof

专利号:CN-101230037-A
优先权日:2008-01-22
标题:A kind of anticancer drug compound and its synthesis method

专利号:JP-2013522243-A
优先权日:2010-03-18
标题 :Methods and processes for the synthesis and production of deuterated ω-diphenylurea