CAS: 519-23-3; 5,11-Dimethyl-6H-Pyrido[4,3-B]Carbazole

上下游产品

1-[1-acetyl-3-(1,1-di-indol-3-yl-ethyl)-1,4-dihydro-[4]pyridyl]-ethanone carbazole2-(p-methoxbenzyl)-1,2,3,4-tetrahydro-5,11-dimethylpyrido4,3-bcarbazole methyllithium naphthyridin-12-one5-hydroxy-5-methyl-indolo1,2-b2,7naphthyridin-12-one6-benzyl-5,11-dimethyl-6H-pyrido[4,3-b]carbazole 2-benzoyl-1-cyano-1,2-dihydroellipticine 2-Benzenesulfonyl-5,11-dimethyl-2,6-dihydro-1H-pyrido[4,3-b]carbazole-1-carbonitrile 6-methylellipticine

📜2-碘苯胺置于盐酸,Lithium Chloro-Isopropyl-Magnesium Chloride,Sodium Azide,三氟化硼乙醚,三氟乙酸,Sodium Nitrite体系中,用 四氢呋喃,二氯甲烷,水,均三甲苯 作为反应溶剂,化学反应 12.75H,反应生成 椭圆玫瑰树碱
参考文献:Preparation Of Polyfunctional Aryl Azides From Aryl Triazenes. A New Synthesis Of Ellipticine,9-Methoxyellipticine,Isoellipticine,And 7-Carbethoxyisoellipticine
标题:Preparation Of Polyfunctional Aryl Azides From Aryl Triazenes. A New Synthesis Of Ellipticine,9-Methoxyellipticine,Isoellipticine,And 7-Carbethoxyisoellipticine
摘要:[graphics]The Preparation Of Polyfunctional Aryl Azides By The Reaction Of Aryl Triazenes With Nan3 In The Presence Of Khso4 Or Bf3 Center Dot Oet2/tfa (Trifluoroacetic Acid) Has Been Described. A Variety Of Functional Groups (Halides,Esters,Ketones,Nitriles,Aldehydes,And Boronic Esters) Are Tolerated Under The Lewis Acidic Conditions. By Using This Methodology,The Potent Antitumor Agents,Ellipticine And 9-Methoxyellipticine,Have Been Synthesized. In Addition,Isoellipticine And A Related Derivative,7-Carbethoxyisoellipticine,Were Also Prepared.
DOI:10.1021/jo070774Z

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

专利号:WO-2013087821-A1
优先权日:2011-12-15
标题:Overproduction of jasmonates in transgenic plants
发明人：CHAMPION ANTONY
权利人:INST RECH DEVELOPPEMENT IRD
摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-2007172520-A1
优先权日:2005-11-18
标题:Immunotargeting of Nonionic Surfactant Vesicles
发明人：VANAUKER MICHAEL; PLAAS ANNA; HOOD ELIZABETH
权利人:UNIV SOUTH FLORIDA
摘要:An immunoniosmes for targeted delivery of therapeutic agents to specific tissues in a host and methods of synthesis of those niosomes. An antibody molecule having specificity for a target antigen, such as a cell surface marker or other marker differentially expressed on a target cell, is covalently coupled to a functionalized membrane constituent. In a particular embodiment the functionalized membrane constituent is polyoxyethylene sorbitan monostearate functionalized with cyanuric chloride. The niosomes of this invention thus provide a composition that enhances internalization or retention of the bioactive agent of the niosome into the cytoplasm of the cells of the target tissue by providing a high degree of target specificity. Furthermore, the membrane vesicle enhances the life of the therapeutic agent by preventing its degradation in the extracellular environment, while exhibiting lower toxicity than can occur with some liposomes. The niosomes of the present invention are thus particularly useful as vehicles for the delivery of therapeutics to specific target cells.

专利号:US-2023288116-A1
优先权日:2022-03-14
标 题:Large scale synthesis of pharmaceutical and biologic formulations using thin film freezing
发明人：OWENS III DONALD E; KOLENG JR JOHN J
权利人:TFF PHARMACEUTICALS INC
摘要:The invention encompasses methods for the large-scale (preferably under cGMP or cGLP standards) preparation of micron-sized or submicron-sized particles including pharmaceutical or biologic active agents. The systems and methods include a cryogenic cooling system including a novel shroud that enhances the cooling effects thereby reducing product loss and increasing product yields.