CAS: 500-62-9; (E)-4-Methoxy-6-(4-Methoxystyryl)-2H-Pyran-2-One

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📜去氢乙酸置于selenium(Iv) Oxide,正丁基锂,硫酸,Sodium Acetate,甲基三苯基碘化膦,Palladium Diacetate,Potassium Carbonate体系中,用 四氢呋喃,1,4-二氧六环,丙酮,乙腈 作为反应溶剂,化学反应 8.42H,反应生成 甲氧醉椒素
参考文献:Heck-Matsuda 芳基化作为获取从远志,Piper Methysticum 和类似物中分离的 Kavalactones 的策略
标题:Heck-Matsuda 芳基化作为获取从远志,Piper Methysticum 和类似物中分离的 Kavalactones 的策略
摘要:在此,我们使用 Heck 描述了从远志(即 1,4 和 7)中分离的三种生物活性吡喃酮和从 Piper Methysticum 中分离出的 8 种(即 8-10,13,15 和 18-20)的全合成-松田芳基化作为关键策略.通过使用不同的芳烃重氮四氟硼酸盐对该方法的评估表明,当进行芳基化的烯烃具有乙烯基-2-吡喃酮结构单元而不是乙烯基二氢-2-吡喃酮部分时,Heck 芳基化更有效.许多被测烯烃的 Heck-Matsuda 芳基化反应以实用的方式进行,具有完全的区域和立体控制.
DOI:10.1002/ejoc.201200308

专利信息

专利号:US-11466283-B2
优先权日:2016-08-18
标 题:Plants and methods for increasing and decreasing synthesis of cannabinoids
发明人：ROSCOW ROBERT F
权利人:CANOPY GROWTH CORP
摘要:This disclosure relates to new plants and methods for increasing and decreasing synthesis of cannabinoids. The plants disclosed herein comprise unnatural ratios and concentrations of cannabinoids in plants of genus Cannabis . The methods disclosed herein comprise manipulating the biosynthetic pathway of cannabinoids to produce plants of genus Cannabis with unnatural ratios and concentrations of cannabinoids.

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-6677462-B2
优先权日:2001-08-06
标题:Asymmetric synthesis of kavalactones
发明人：CHEN SHOUJUN; SUN LIJUN; MCCLEARY JOEL
权利人:KAVA PHARMACEUTICALS INC
摘要:This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.

专利号:US-2019271015-A1
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains

专利号:US-10941429-B2
优先权日:2018-01-17
标 题:Enzymatic synthesis of kavalactones and flavokavains

专利号:CA-2456720-A1
优先权日:2001-08-06
标题 :Asymmetric synthesis of kavalactones