CAS: 4981-63-9; 1-(4-Chlorophenyl)Butan-1-One

上下游产品

butyryl chloride chlorobenzene butanoic acid anhydride N,N,N,N,N,N-hexamethylphosphoric triamide 1-(4-chloro-phenyl)-butane-1,2-dione-2-oxime 4-n-butylchlorobenzene 4-n-butanoyl-2-nitr°Chlorobenzene 1-[(E)-(but-1-en-1-yl)]-4-chlorobenzene

📜1-(4-Chlorophenyl)But-2-En-1-Ol置于dichlorocobalt;2-Diphenylphosphanyl-N-(2-Diphenylphosphanylethyl)Ethanamine体系中,用 乙醇 作为反应溶剂,化学反应 4.0H,以57%的收率获得产物4'-氯苯丁酮
参考文献:钴pnp夹钳催化剂将烯丙醇无添加剂异构化为酮
标题:钴pnp夹钳催化剂将烯丙醇无添加剂异构化为酮
摘要:通过在不存在任何添加剂的情况下使用空气和湿气稳定的钴(II)配合物,可以实现烯丙醇在乙醇中的催化异构化(绿色溶剂).在温和的条件下,被磷原子上的苯基取代的钴pnp钳形络合物似乎是活性最高的.即使加入一当量的碱可大大提高反应速度,但在120oc时仍可获得较高的反应速率.尽管获得了支持脱氢-加氢机理的一些证据,但已证明这不是主要机理.取而代之的是,乙醇脱氢形成的氢化钴配合物能够通过烯烃插入-消除反应实现双键异构化.
DOI:10.1002/chem.201901148

专利信息

专利号:US-8067460-B2
优先权日:2004-10-04
标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel
发明人：WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA
权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA
摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:US-2014350005-A1
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use

专利号:WO-2011160084-A1
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use

专利号:US-2012010228-A1
优先权日:2010-06-18
标 题 :D2 antagonists, methods of synthesis and methods of use

专利号:EP-3138841-A1
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use