CAS: 4965-09-7; 1-Methyl-1,2,3,4-Tetrahydroisoquinoline

相似化合物

111635-08-6 64982-61-2 84010-66-2

上下游产品

(S)-1-methyl-1,2,3,4-tetrahydroisoquinoline cyclopropanecarboxylic acid chloride phenethylamine 1-methyl-3,4,dihydroisoquinoline N-(4-nitrophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline N-(2-nitrophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline N-benzoyl-1-methyl-1,2,3,4-tetrahydroisoquinoline N-methyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

3,4-二氢异喹啉-2(1H)-甲醛置于正丁基锂,Triethyloxonium Fluoroborate,一水合肼,溶剂黄146,三乙胺,二异丙胺体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 1.08H,反应生成 (S)-1-甲基-1,2,3,4-四氢异喹啉
参考文献:α-氨基碳负离子的对映选择性烷基化:(S)-1-烷基-1,2,3,4四氢异喹啉的合成
标题:α-氨基碳负离子的对映选择性烷基化:(S)-1-烷基-1,2,3,4四氢异喹啉的合成
摘要:一系列转化为1,2,3,4-四氢异喹啉的甲am衍生物的手性氨基醇被评估为手性偶极稳定的阴离子.用卤代烷进行烷基化可得到1-烷基-1,2,3,4-四氢异喹啉,它们的收率和对映体纯度都很高.
DOI:10.1016/s0040-4020(01)82421-2

专利信息

专利号:WO-02088088-A9
优先权日:2001-04-27
标题 :Process for preparing 1-methyl-1,2,3,4-tetrahydroisoquinoline or a salt thereof
发明人：BREEN GARY FRANCIS; FORTH MICHAEL ANTHONY; POPKIN MATTHEW EDWARD
权利人:SB PHARMCO INC; BREEN GARY FRANCIS; FORTH MICHAEL ANTHONY; POPKIN MATTHEW EDWARD
摘要:The invention provides a process for preparing 1-methyl-1,2,3,4-tetrahydroisoquinoline of formula (A), or a salt thereof, the process comprising: (i) reacting N-(2-chloroethyl)-α-methylbenzylamine of formula (B), or a salt thereof, with a Lewis acid such as AlCl3, and (ii) causing or allowing cyclisation to 1-methyl-1,2,3,4-tetrahydroisoquinoline. The invention also provides a process for preparing 1-methyl-1,2,3,4-tetrahydroisoquinoline of formula (A), or a salt thereof, the process comprising: (i) reacting a N-(2-haloethyl)-α-methylbenzylamine, or a salt thereof, with a Lewis acid and (ii) causing or allowing cyclisation to 1-methyl-1,2,3,4-tetrahydroisoquinoline at a temperature of ≤130°C. The use of N-(2-chloroethyl)-α-methylbenzylamine and/or lower cyclisation temperatures decreases the amount of certain impurities formed in the reaction. In other aspects of the invention, the 1-methyl-1,2,3,4-tetrahydroisoquinoline can be used in the synthesis of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine (SB 641257, YH1885), a pharmaceutically active reversible proton pump inhibitor.

专利号:CN-118421581-A
优先权日:2024-04-28
标题 :Imine reductase and its application in the synthesis of (S)-1-methyl-1,2,3,4-tetrahydroisoquinoline

专利号:CN-113072493-A
优先权日:2021-03-23
标题 :A new method for the synthesis of 1-fluoromethyl-tetrahydroisoquinoline derivatives

专利号:CN-118516325-A
优先权日:2024-06-04
标 题:An immobilized enzyme biocatalyst and its application in catalytic synthesis of (S)-1-methyl-1,2,3,4-tetrahydroisoquinoline