CAS: 41191-92-8; Ethyl 3-Amino-4-Methylbenzoate

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CAS号19013-15-1 4-甲基-3-硝基苯甲酸乙酯 | CAS号96-98-0 4-甲基-3-硝基苯甲酸 | CAS号64-17-5 乙醇 | CAS号2458-12-0 3-氨基-4-甲基苯甲酸 | CAS号147962-81-0 3-溴-4-甲基苯甲酸乙酯 | CAS号916902-55-1 1H-吲唑-6-甲醇 | CAS号641569-96-2 3-[(氨基亚胺甲基)氨基]-... | CAS号713-09-7 1h-吲唑-6-羧酸乙酯 | CAS号641569-94-0 4-甲基-3-[[4-(3-吡... | CAS号113641-88-6 ethyl 3-bromo-4... | CAS号845884-82-4 3-AMINO-4-METHY...

4-甲基-3-硝基苯甲酸置于palladium 10% On Activated Carbon,甲酸铵,对甲基苯甲酸体系中,用 甲醇,甲苯 作为反应溶剂,化学反应生成 3-氨基-4-甲基苯甲酸乙酯
参考文献:一种制备n-(5-羧基-2-甲基苯基)-4-(3-吡啶)-2-嘧啶胺的方法
标题:一种制备n-(5-羧基-2-甲基苯基)-4-(3-吡啶)-2-嘧啶胺的方法
摘要:本发明公开了一种制备n‑(5‑羧基‑2‑甲基苯基)‑4‑(3‑吡啶)‑2‑嘧啶胺的方法,具体包括一下步骤:步骤1,该合成路线以3‑硝基‑4‑甲基苯甲酸为起始原料经乙酯化反应反应生成化合物2;步骤2,化合物2的硝基经钯碳氢化还原反应反应生成化合物3;步骤3,化合物3与腈胺水溶液反应,再经盐基互换得到化合物4;步骤4,化合物4与化合物6环合得到化合物7;步骤5,化合物7在碱性的作用下水解反应生成化合物8即n‑(5‑羧基‑2‑甲基苯基)‑4‑(3‑吡啶)‑2‑嘧啶胺,本发明方法克服了现有技术存在的反应时间长,收率低,成本高,不利于工业化生产的缺陷,提供了一种收率高,环保经济十分适合工业化生产的制备方法.

专利信息

专利号:US-4080355-A
优先权日:1975-10-23
标题:Quinacridones and synthetic fibers dyed therewith
发明人：LE PAPE ALAIN YVES
权利人:UGINE KUHLMANN
摘要:Quinacridone compounds are disclosed which may be represented by the general formula: ##STR1## wherein X represents hydrogen or hydroxy; n Y represents hydroxyalkoxy containing 1 to 4 carbon atoms, preferably 1 to 2 carbon atoms or carboxylic ester COOR; n R represents alkyl which preferably contains 1 to 4 carbon atoms; and n Z represents hydrogen or halogen, preferably chlorine or bromine, or alkyl or alkoxy containing 1 to 4 carbon atoms, preferably 1 to 2 carbon atoms. n These quinacridones can be used for the dyeing of synthetic fibers such as polyesters and polyamides and for the synthesis of structurally dyed copolyesters.

专利号:CN-110872279-A
优先权日:2019-12-13
标 题 :A kind of high-yield synthesis method of Nilotinib

专利号:CN-110872279-B
优先权日:2019-12-13
标题 :A high-yield synthesis method of nilotinib