CAS: 394-33-2; 4-Fluoro-2-Nitrophenol

上下游产品

CAS号371-41-5 4-氟苯酚 | CAS号446-09-3 1-溴-4-氟-2-硝基苯 | CAS号445-83-0 4-氟-2-硝基苯甲醚 | CAS号119-34-6 2-硝基-4-氨基苯酚 | CAS号459-60-9 4-氟苯甲醚 | CAS号364-78-3 4-氟-2-硝基苯胺 | CAS号42864-24-4 2-cyano-3,4-dim... | CAS号364-74-9 2,5-二氟硝基苯 | CAS号321-04-0 1-ethoxy-4-fluo... | CAS号371-40-4 4-氟苯胺 | CAS号399-97-3 2-氨基-4-氟苯酚 | CAS号387-97-3 5-氯-8-喹啉丙烯酸 | CAS号398-63-0 6-氟-2H-1,4-苯并噁唑... | CAS号445-83-0 4-氟-2-硝基苯甲醚 | CAS号701-16-6 5-氟-2-甲基苯并恶唑 | CAS号105655-00-3 6-氟-3,4-二氢-2h-苯... | CAS号13451-78-0 5-氟苯并噁唑-2-硫醇 | CAS号1978-39-8 5-氟-2-甲氧基苯胺 | CAS号722536-28-9 4-Fluoro-2-nitr...

对氟苯甲醚置于氢溴酸,硝酸,乙酸酐,溶剂黄146体系中,化学反应生成2-硝基-4-氟苯酚
参考文献:Swarts,Recueil Des Travaux Chimiques Des Pays-Bas,1916,Vol. 35,P. 142
标题:Swarts,Recueil Des Travaux Chimiques Des Pays-Bas,1916,Vol. 35,P. 142

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

专利号:CN-118388379-A
优先权日:2024-04-19
标题 :Organic total synthesis method of nimesulide derivative