CAS: 28978-02-1; 5-Hydroxy-6-Methoxy-2-(4-Methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Methyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

该化合物是一种自然形成的花粉胶质,主要存在于Cirsinum和Linaria物种等植物中,因其潜在的生物活性特性而得到承认,包括抗氧化剂,抗炎和肝脏保护效应.在结构上,它包括一种与甘糖结合的花粉脊柱,增强了其溶性和生物利用率.Pectolinarin在调节细胞路径方面的作用,特别是在减少氧化性压力和炎症方面的作用已经进行了研究.其稳定性和低毒性特征使得它成为药物和营养素应用的候选物.研究继续探索其机制和治疗潜力,特别是在新陈代谢和与肝脏有关的疾病方面.

结构式图片

上下游产品

CAS号4154-21-6 acetone oxime h... | CAS号520-12-7 柳穿鱼黄素

合成工艺路线路线简述

    Acetylpectolinarin置于氢氧化钾体系中,化学反应 0.5H,反应生成大蓟苷
    参考文献:Flavonoids Of The Epigeal Part Ofkickxia Elatine
    标题:Flavonoids Of The Epigeal Part Ofkickxia Elatine
    摘要:
    Doi:10.1007/bf01373784

    专利信息


    专利号:US-2002165207-A1
    优先权日:2001-05-02
    标题 :Compositions and methods for the treatment of diabetic neuropathy
    发明人:ROSENBLOOM RICHARD
    摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.
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    合成参考文献


    参考文献:10.1248/bpb.31.760
    摘要:Yoo YM, Nam JH, Kim MY, Choi J, Park HJ. Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism. Biol Pharm Bull. 2008 Apr;31(4):760–4. doi: 10.1248/bpb.31.760.
    参考文献:10.1016/s0031-9422(02)00192-9
    摘要:Grayer RJ, Veitch NC, Kite GC, Paton AJ, Garnock-Jones PJ. Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). Phytochemistry. 2002 Aug;60(7):727–31. doi: 10.1016/s0031-9422(02)00192-9.
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