CAS: 26250-84-0; (S)-1-(Tert-Butoxycarbonyl)Piperidine-2-Carboxylic Acid

上下游产品

CAS号7681-38-1 硫酸氢钠 | CAS号13406-98-9 哌啶-1-羧酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号3105-95-1 L-哌啶酸 | CAS号417726-36-4 (S)-N-B°C-1,2,3... | CAS号15912-30-8 (2R,3R)-2,3-dih... | CAS号124-38-9 二氧化碳 | CAS号75844-69-8 1-B°C-哌啶 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号53123-88-9 雷帕霉素 | CAS号242459-44-5 (S)-1-B°C-2-氰基哌 | CAS号27262-40-4 (S)-N-(2,6-二甲基苯... | CAS号78058-41-0 N-叔丁氧羰基-L-2-哌啶甲酰胺 | CAS号134441-93-3 (S)-N-B°C-2-哌啶甲醇 | CAS号131134-77-5 N-B°C-2-哌啶乙酸甲酯 | CAS号150521-32-7 (S)-2-甲酰基哌啶-1-甲酸叔丁酯 | CAS号199942-74-0 (S)-1-N-B°C-哌啶-2-乙醇 | CAS号18650-39-0 (S)-哌啶-2-甲酸甲酯盐酸盐 | CAS号200184-53-8 1-b°C-哌啶-2-羧酸-S-甲酯

哌啶酮置于ruthenium(II) Chloride,4-二甲氨基吡啶,R-(+)-1,1'-联萘-2,2'-双二苯膦 正丁基锂,四甲基乙二胺,氢气,二异丁基氢化铝,对甲苯磺酸体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,甲苯,乙腈 用作溶剂,-78.0~45.0 °C,6.89 Mpa 条件下,反应 14.41H,反应生成N-Boc-L-哌啶-2-羧酸
参考文献:对映选择性合成2-烷基-和2,6-二烷基哌啶生物碱:(-)-Coniine,(-)-Solenopsin A和(-)-Dihydropinidine盐酸盐的制备.
标题:对映选择性合成2-烷基-和2,6-二烷基哌啶生物碱:(-)-Coniine,(-)-Solenopsin A和(-)-Dihydropinidine盐酸盐的制备.
摘要:[反应:见正文]锂化-取代,对映选择性氢化和非对映选择性锂化-取代的序列提供了2-取代的和顺式和反式2,6-二取代的哌啶的高效高对映选择性的合成.该方法论通过合成(-)-芥氨酸,(-)-血脂素a和(-)-二氢吡啶为盐酸盐来证明.
Doi:10.1021/ol9912534

专利信息

专利号:US-10456387-B2
优先权日:2011-11-29
标 题:Phacetoperane for treating of attention deficit hyperactivity disorder
发明人：KONOFAL ERIC; FIGADERE BRUNO
权利人:NLS PHARMA AG; NLS PHARMACEUTICS AG
摘要:The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.

专利号:US-12428442-B2
优先权日:2017-06-21
标题 :Compounds, compositions and methods for synthesis
发明人：BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
权利人:WAVE LIFE SCIENCES LTD
摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

专利号:US-9879050-B2
优先权日:2013-08-30
标 题 :Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; GRIFFITH ELIZABETH; ZHENG ZHONG; SINGH AMAN P
权利人:ST JUDE CHILDREN'S RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-10570179-B2
优先权日:2016-09-02
标 题:Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
发明人：LEE RICHARD E; ZHAO YING
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-10822377-B2
优先权日:2015-03-04
标 题:Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
发明人：LEE RICHARD E; ZHAO YING; JIUYU LIU
权利人:ST JUDE CHILDRENS RES HOSPITAL
摘要:In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2019092808-A1
优先权日:2016-02-04
标题 :Synthesis and composition of rapafucin libraries