专利号:US-6229055-B1 优先权日:1996-04-12 标题 :Synthesis of fluorinated xanthene derivatives 发明人:KLAUBERT DIETER H; GEE KYLE R 权利人:MOLECULAR PROBES INC 摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
专利号:CN-117466729-A 优先权日:2023-12-28 标题:A kind of synthesis method of 2,4,5-trifluorophenylacetic acid
专利号:US-5756834-A 优先权日:1995-11-11 标 题:Process for preparing fluorinated aromatics 发明人:PASENOK SERGEJ; APPEL WOLFGANG 权利人:HOECHST AG 摘要:It is known to prepare fluorinated aromatic compounds of the formula I in which X, Y and Z can have the meaning specified in the description, by reacting aromatic compounds of the formula II in which X, Y and Z have the meaning specified for formula I, with fluorine in a reaction medium. According to the invention, the direct fluorination is carried out in a reaction medium containing polyfluoroalkanesulfonic acids of the formula IIICFnH3-n(CFY)m-SO3H(III)in which m, n and Y have the meaning specified in the description. By this means, it is possible, particularly advantageously to provide a process, which improves the known processes not only with regard to the selectivity and the yield, but also with respect to the quality of the resulting products of the process in a manner not readily predictable. Fluorinated aromatic compounds of the formula I as intermediates for active compound synthesis.
专利号:CN-119977815-A 优先权日:2025-02-11 标 题:Synthesis method of 3-bromo-5-fluoro-2, 4-dimethylaniline and intermediate compound thereof
参考文献:10.1055/s-0033-1338535 摘要:Woydziak ZR, Fu L, Peterson BR. Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular Probes. Synthesis (Stuttg). 2014 Jan 01;46(2):158–64.