CAS: 172606-22-3; 1,4-Bis((3,5-Dimethyl-1H-Pyrazol-1-yl)Methyl)Benzene

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1134-81-2 2247034-62-2 172606-24-5

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3,5-dimethyl-1H-pyrazole 1,4-bis(bromomethyl)benzene p-Xylylene dichloride para-xylene 1,1'-(benzene-1,4-diyldimethylene)-bis(3,5-dimethyl-1H-pyrazole-4-carbaldehyde)

📜对二甲苯置于溴,Potassium Hydroxide体系中,用 二甲基亚砜 用作溶剂,化学反应 6.0H,反应生成1,4-双((3,5-二甲基-1H-吡唑-1-基)甲基)苯
参考文献:Synthesis,Structural,And Biological Evaluation Of The Arene-Linked Pyrazolyl Methane Ligands And Their D9/d10 Metal Complexes
标题:Synthesis,Structural,And Biological Evaluation Of The Arene-Linked Pyrazolyl Methane Ligands And Their D9/d10 Metal Complexes
摘要:A Series Of The P-Bis[(1-Pyrazolyl)Methyl] Benzene Ligands (L-1-L-6) In The Dmso System Were Synthesized. In The Mean Time,By Using The Ligands As A Linker,A New Family Of Transition Metal Coordination Polymers,Namely,[cu-2(L-1)(2)Cl-4] (1),[cu-2(L-2)(2)Cl-4] (2),[ag(L-2)(No3)] (3). [zn-2(L-2)(2)(Scn)(4)] (4) And [cd-2(L-2)(Scn)(4)] (5) [l-1 = 1,4-Bis((1H-Pyrazol-1-yl)Methyl)Benzene; L-2 = 1,4-Bis(3,5-Dimethyl-1H-Pyrazol-1-yl)Methyl)Benzene] Have Been Constructed By The Reaction Of The P-Bis[(1-Pyrazolyl)Methyl]Benzene And Corresponding To The Transition Metal Compounds In A Mixed Solution Of Ch3Oh/c2H5Oh At Mild Temperature Condition. All The Coordination Polymers And P-Bis[(1-Pyrazolyl)Methyl]Benzene Ligands Were Characterized By Elemental Analysis,Ir Spectroscopy,H-1 NMR And C-13 NMR,And Some Of Them Were Characterized By Uv Spectroscopy,Thermogravimetric Analysis,X-Ray Powder And X-Ray Single-Crystal Diffraction. Structural Analyses Reveal That The Ligands L-3-L-5 (L-3 = 1,4-Bis((4-Iodo-1H-Pyrazol-1-yl)Methyl)Benzene,L-4 = 1,4-Bis((4-Iodo-3,5-Dimethyl-1H-Pyrazol-1-yl)Methyl)Benzene,L-5 = 1,4-Bis((4-Nitro-1H-Pyrazol-1-yl)Methyl) Benzene,L-6 = 1,4-Bis((4-Nitro-3,5-Dimethyl-1H-Pyrazol-1-yl) Methyl) Benzene) Are Discrete Organic Compound Molecules And The Complexes 1-5 Are 1D M-L-M Coordination Polymers,Which Are Further Interlinked Via Hydrogen Bonds Resulting In 2D Or Even 3D Supermolecular Networks. The Luminescent Properties Of The Coordination Polymers 3,4 And 5 Were Examined By Luminescence Spectra. The Analytic Results Indicate That Different Metal Complexes With The Same Ligand Have Different Influence On The Characteristic Photoluminescence. Furthermore,The Cytotoxicity Of The Ligands L-1-L-6 And Complexes 1-5 Were Evaluated Against Hepg2 Cells. For The Ligands Of L-1-L-6,The Different Substituents Of The Pyrazole Ring Slightly Influenced The Cytotoxicity Of The Cell. It Is Found That Nitro-Compounds Have Shown The Highest Cytotoxicity Under The Same Concentration Condition. The Cytotoxic Activity Of The Complexes 1-5 Are Strongly Increased By The Introduction Of The Transition Metals. (C) 2012 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Poly.2012.08.016