专利号:US-2007122842-A1 优先权日:2005-11-30 标题 :Massively parallel synthesis of proteinaceous biomolecules 发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-2007122841-A1 优先权日:2005-11-30 标题:Massively parallel synthesis of proteinaceous biomolecules 发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-9499578-B2 优先权日:2005-12-29 标题 :Massively parallel synthesis of biopolymeric arrays 发明人:RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN 权利人:RAJASEKARAN JOHN J; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; TIWARI GUNJAN; INTEL CORP 摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
专利号:US-6512054-B2 优先权日:2000-01-19 标题 :Synthesis of free racdical or visible light curable acid containing polymers 发明人:CULBERTSON BILL M; SCHRICKER SCOTT R 权利人:UNIV OHIO STATE RES FOUND 摘要:Methods for preparing free radical or visible light curable (VLC) acid-containing polymers in an aqueous solution are provided. In one embodiment, the method comprises reacting polymers having reactive carboxylic acid groups with a methacrylated oxazoline or oxazine, collectively referred to hereafter as “methacrylated unsaturated cyclic imino ethers,â€? in an aqueous solution at a temperature of from about 50° C. to about 75° C. In another embodiment, the method comprises an additional step of preparing the carboxylic acid-containing polymer in an aqueous solution and then reacting the carboxylic acid-containing polymer with the methacrylated cyclic imino ether in the aqueous solution. The present invention also relates to free radical or VLC acid-containing polymers, and dental restoratives that comprise such polymers. Methods of attaching an oxazoline or oxazine to a carboxylate group on a polymer in an aqueous solution are also provided.
专利号:US-4710513-A 优先权日:1979-08-17 标 题:Substituted pyranone inhibitors of cholesterol synthesis 发明人:WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J 权利人:MERCK & CO INC 摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
专利号:US-8183409-B2 优先权日:2004-05-06 标题:High yield and rapid synthesis methods for producing metallo-organic salts 发明人:CHRISTGAU STEPHAN; ANDERSEN JENS E T 权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS 摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.