CAS: 13748-90-8; (S)-2-Hydroxy-4-Methylpentanoic Acid

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CAS号61-90-5 L-亮氨酸 | CAS号171598-10-0 ethyl (S)-2-bro... | CAS号816-66-0 4-甲基-2-氧戊酸 | CAS号50364-35-7 L-α-Aminooxy-γ-... | CAS号328-39-2 (±)-氨基-4-甲基戊酸 | CAS号1342309-24-3 trichodepsipeptide B | CAS号646-07-1 4-甲基戊酸 | CAS号10303-64-7 DL-白氨酸 | CAS号310404-45-6 (2R)-2-[(1,3-二氢... | CAS号3069-52-1 L-2-羟基-4-甲基戊酸叔丁酯 | CAS号20312-37-2 (R)-2-羟基-4-甲基戊酸 | CAS号60856-85-1 (S)-(-)-Ethyl L... | CAS号380886-35-1 2-[(1,3-二氢-1,3-...

4-甲基-2-氧代戊酸置于还原型辅酶ⅰ体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应生成L-Alpha-羟基异己酸
参考文献:L-α-氨基酸的生物控制形式转化或保留为对映纯(R)-或(S)-羟基酸
标题:L-α-氨基酸的生物控制形式转化或保留为对映纯(R)-或(S)-羟基酸
摘要:天然的l-α-氨基酸和l-正亮氨酸通过正式的生物催化转化或保留绝对构型而转化为相应的α-羟基酸.通过在水性介质中同时进行氧化还原级联反应来实现单锅转化.具有高分离度(67-85%)和对映纯形式(> 99%ee)的高分离度分离了具有脂肪族,芳香族和杂芳族部分的对映体(R)-和(S)-2-羟基酸的代表小组,而无需进行色谱纯化.
Doi:10.1002/chem.201403195

专利信息

专利号:WO-2008151306-A1
优先权日:2007-06-05
标题 :Synthesis of cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity
发明人：PETTIT GEORGE R; SMITH THOMAS H; FENG SONG
权利人:UNIV ARIZONA; PETTIT GEORGE R; SMITH THOMAS H; FENG SONG
摘要:The present invention is directed to effective methods of synthesizing cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity. Total syntheses of the eighteen-membered ring cyclodepsipeptides kitastatin (1a) and respirantin (1b) are taught. One important step in the synthesis is an intramolecular transesterification of the ?-ketoester alcohol 6 to afford the protected macrocycle 5. The synthetic products were shown to be identical to the natural products and the absolute stereochemistry of 6 of the 7 asymmetric centers of cyclodepsipeptide 1b was unequivocally established. Kitastatin (1a) and respirantin (1b) were found to be remarkable inhibitors of cancer cell growth and are related to the antimycin family of antibiotics.

专利号:US-2009123983-A1
优先权日:2007-10-03
标 题:Processes for preparing an intermediate of sitagliptin via enzymatic reduction
发明人：NIDDAM-HILDESHEIM VALERIE
权利人:NIDDAM-HILDESHEIM VALERIE
摘要:The invention provides enzymatic reduction processes for the preparation of 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, particularly, (S)-methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, a key intermediate in the synthesis of Sitagliptin, and the (S)- and (R)-enantiomers of methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate in high enantiomeric purity.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-12157908-B2
优先权日:2019-02-25
标 题:Cell-free protein synthesis platforms derived from clostridia extracts
发明人：JEWETT MICHAEL CHRISTOPHER; KRUGER-GERICKE ANTJE; MUELLER ALEXANDER PAUL; KOEPKE MICHAEL
权利人:UNIV NORTHWESTERN; LANZATECH INC
摘要:Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from a species of Clostridia such as cellular extracts from Clostridium autoethanogenum.

专利号:EP-0830136-B1
优先权日:1995-03-07
标 题:New cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; HEMSCHEIDT THOMAS K; GOLAKOTI TRIMURTULU
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.

专利号:US-6013626-A
优先权日:1993-12-21
标题 :Cryptophycins from synthesis
发明人：MOORE RICHARD E; TIUS MARCUS A; BARROW RUSSELL A; LIANG JIAN; CORBETT THOMAS H; VALERIOTE FREDERICK A; GOLAKOTI TRIMURTULU; HEMSCHEIDT THOMAS K
权利人:UNIV HAWAII; UNIV WAYNE STATE
摘要:A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.