CAS: 13316-12-6; 7-Chlorothiazolo[5,4-D]Pyrimidine

该化合物是一种杂环化合物,其特点是独特的双环结构,它包括硫诺和铁环;7号位置存在氯原子,有助于其反应和潜在的生物活动;该化合物一般在室温下是固体,根据具体情况,在有机溶剂中可能表现出中等溶解性;其分子结构表明,由于氮和硫原子的存在,药物化学在医药化学中,特别是在药物研制中的潜在应用,这可能影响该化合物与生物目标的互动.此外,由于硫和硫原子在不同生物过程中的作用,人们都知道,硫诺和铁在各种生物过程中的作用,因此在与......

英文名称7-Chlorothiazolo[5,4-D]Pyrimidine
中文名称7-氯噻唑并[5,4-d]嘧啶
IUPAC名称7-chlorothiazolo[5,4-d]pyrimidine
其它别名7-Chloro-[1,3]Thiazolo[5,4-D]Pyrimidine
CAS编号13316-12-6
MFCD编号:MFCD16657018
EINECS号:842-631-1
分子式:C5H2ClN3S
分子量:171.61
产品CID: 498834
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: HGYFXAHDBRHZGF-UHFFFAOYSA-N
InChI=1S/C5H2ClN3S/c6-4-3-5(8-1-7-4)10-2-9-3/h1-2H…
计算化学: 氢键受体数4.0氢键供体数0可旋转键数0

相似化合物

13479-88-4 13316-09-1 19602-61-0

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

CAS号122-51-0 原甲酸三乙酯 | CAS号54851-35-3 5-氨基-6-氯-1H-嘧啶-4-硫酮

合成工艺路线路线简述

噻唑并[5,4-D]嘧啶-7(4H)-酮置于三氯氧磷体系中,化学反应生成7-氯噻唑并[5,4-D]嘧啶
参考文献:Stimulation Of Cortical Bone Formation With Thienopyrimidine Based Inhibitors Of Notum Pectinacetylesterase
标题:Stimulation Of Cortical Bone Formation With Thienopyrimidine Based Inhibitors Of Notum Pectinacetylesterase
摘要:A Group Of Small Molecule Thienopyrimidine Inhibitors Of Notum Pectinacetylesterase Are Described. We Explored Both 2-((5,6-Thieno[2,3-D]Pyrimidin-4-yl)Thio)Acetic Acids And 2-((6,7-Thieno[3,2-D]Pyrimidin-4-yl)Thio)Acetic Acids. In Both Series,Highly Potent,Orally Active Notum Pectinacetylesterase Inhibitors Were Identified. (C) 2016 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2016.02.021

专利信息

专利号:US-12054512-B2
优先权日:2017-11-10
标题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.