CAS: 133-51-7; Methylglucamine Antimonate

该化合物是一种协调复合体,它是由N-甲基甘油胺(在制药和化学应用中通常用作抗甲胺剂的抗甲胺)的反应形成的,其主要优点包括水溶性高,水溶性高,可提高生物利用率,便于在治疗制剂中进行配方.该复合体显示出强烈的悬浮特性,改善了抗虫剂的稳定性,并在医疗中控制地释放了抗虫剂,特别是利什曼病等寄生虫感染.其定义明确的分子结构确保了研究和工业过程的一贯性能.此外,N-M-甲基甘油抗甲酸酯与其他抗甲酸盐化合物相比毒性较低,因此在生物医学应用方面是一个更安全的选择.

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欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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    专利信息


    专利号:US-9382288-B2
    优先权日:2010-10-06
    标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
    发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
    权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
    摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

    专利号:WO-9925385-A1
    优先权日:1997-11-17
    标 题:A method of increasing nucleic acid synthesis with ultrasound
    发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
    权利人:IMARX PHARMACEUTICAL CORP
    摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

    专利号:US-9562037-B2
    优先权日:2014-02-26
    标题:Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
    发明人:CHOW LARRY MING-CHEUNG; CHAN WILLIAM TAK HANG; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
    权利人:UNIV HONG KONG POLYTECHNIC
    摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

    专利号:US-10111854-B2
    优先权日:2014-02-26
    标题 :Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
    发明人:CHOW LARRY MING-CHEUNG; Chan Tak Hang William; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
    权利人:UNIV HONG KONG POLYTECHNIC
    摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

    专利号:US-9061984-B2
    优先权日:2008-08-15
    标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
    发明人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
    权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
    摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

    专利号:US-6797819-B1
    优先权日:1998-06-11
    标 题 :Alkaloids
    发明人:SHAIR MATTHEW; WESTWOOD NICHOLAS; PELISH HENRY EFREM; KIRCHHAUSEN THOMAS; FENG YAN
    权利人:HARVARD COLLEGE; CBR INST FOR BIOMED RES INC
    摘要:The present invention provides novel alkaloid compounds and collections of these compounds, and provides methods for the synthesis of these compounds using biomimetic synthetic strategies. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as bacterial infections, proliferative diseases, and reproductive disorders, to name a few.
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    合成参考文献


    参考文献:10.3341/kjo.2010.24.1.40
    摘要:Yaghoobi R, Maraghi S, Bagherani N, Rafiei A. Cutaneous leishmaniasis of the lid: a report of nine cases. Korean J Ophthalmol. 2010 Feb;24(1):40–3.
    参考文献:10.1016/j.exppara.2011.06.016
    摘要:dos Santos AO, Costa MA, Ueda-Nakamura T, Dias-Filho BP, da Veiga-Júnior VF, de Souza Lima MM, Nakamura CV. Leishmania amazonensis: effects of oral treatment with copaiba oil in mice. Exp Parasitol. 2011 Oct;129(2):145–51. doi: 10.1016/j.exppara.2011.06.016.
    参考文献:10.1097/dad.0b013e31820977d1
    摘要:Quintella LP, Cuzzi T, de Fátima Madeira M, Valete-Rosalino CM, de Matos Salgueiro M, de Camargo Ferreira e Vasconcellos E, Mouta-Confort E, Lambert Passos SR, de Oliveira Schubach A. Cutaneous leishmaniasis with pseudoepitheliomatous hyperplasia simulating squamous cell carcinoma. Am J Dermatopathol. 2011 Aug;33(6):642–4. doi: 10.1097/dad.0b013e31820977d1.
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