CAS: 1193687-87-4; Raltegravir Related Compound E

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2-(2-Aminopropan-2-yl)-N-Benzyl-1,6-Dihydro-5-Hydroxy-1-Methyl-6-Oxopyrimidine-4-Carboxamide 1403457-41-9

📜在 N-甲基吗啉,甲烷磺酸,10% Pd/c,氢气体系中,用 四氢呋喃,甲醇,乙腈 用作溶剂,55.0 °C,200.0 Kpa 条件下,反应 1.0H,反应生成雷特格韦相关化合物e(Usp)
参考文献:Identification,Synthesis,And Strategy For Minimization Of Potential Impurities Observed In Raltegravir Potassium Drug Substance
标题:Identification,Synthesis,And Strategy For Minimization Of Potential Impurities Observed In Raltegravir Potassium Drug Substance
摘要:Multiple Sources Of Anticipated Degradation And Process Impurities Of Raltegravir Potassium Drug Substance Observed During The Laboratory Optimization And Later During Its Bulk Synthesis Are Described In This Article. The Impurities Were Monitored By Uplc,And Their Structures Are Tentatively Assigned On The Basis Of Fragmentation Patterns In Lc-Ms And NMR Spectroscopy. Most Of The Impurities Are Synthesized,And Their Assigned Constitutions Were Confirmed By Co-Injection In Uplc. In Addition To The Formation,Synthesis,And Characterization,Strategy For Minimizing These Impurities To The Level Accepted By Ich Is Also Described. We Feel That Our Study Will Be Helpful To The Generic Industry For Obtaining Chemically Pure Raltegravir Potassium.
Doi:10.1021/op300077M