专利号:US-2012177593-A1 优先权日:2009-07-20 标 题 :Synthesis of dendrimer conjugates 发明人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH 权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN 摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
专利号:US-2024294464-A1 优先权日:2021-10-27 标题 :Synthesis of restrained complexing agents 发明人:WONG NICHOLAS; GOSSELIN FRANCIS 权利人:GENENTECH INC 摘要:Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.
专利号:US-8735586-B2 优先权日:2007-06-26 标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR 权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-2007249867-A1 优先权日:2004-08-11 标题 :Method for Synthesis of Aromatic Amine 发明人:NAKASHIMA HARUE; KAWAKAMI SACHIKO 权利人:NAKASHIMA HARUE; KAWAKAMI SACHIKO 摘要:One embodiment of the present invention provides a method for synthesis of substituted secondary amine by the reaction of aniline with aryl halide by using a Pd catalyst including (t-Bu) 3 P as a ligand.
专利号:US-7759492-B2 优先权日:2004-08-20 标 题:Enantioselective synthesis of 13-oxotricyclo[8.2.1.0.3,8] trideca-3(8),4,6-triene-5-carboxylates 发明人:KEEN STEPHEN PHILIP; OLIVER STEVEN FRASER; STEWART GAVIN WILLIAM 权利人:MERCK SHARP & DOHME 摘要:An enantioselective route to compounds of formula I is disclosed: n n n n n n n n n n The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease.
专利号:US-9006425-B2 优先权日:2009-03-18 标题:Aluminum complexes and their use in the synthesis of cyclic carbonates 发明人:NORTH MICHAEL 权利人:NORTH MICHAEL; UNIV YORK 摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.
参考文献:10.1080/01635580903285106 摘要:Patel BB, Majumdar APN. Synergistic Role of Curcumin With Current Therapeutics in Colorectal Cancer: Minireview. Nutrition and Cancer. 2009 Nov 10;61(6):842–6. doi: 10.1080/01635580903285106. 参考文献:10.2174/157016210791111061 摘要:Berretta M, Lleshi A, Cappellani A, Bearz A, Spina M, Talamini R, Cacopardo B, Nunnari G, Montesarchio V, Izzi I, Lanzafame M, Nasti G, Basile F, Berretta S, Fisichella R, Schiantarelli C C, Garlassi E, Ridolfo A, Guella L, Tirelli U. Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection. Curr HIV Res. 2010 Apr;8(3):218–22. doi: 10.2174/157016210791111061. 参考文献:10.1007/s00280-005-0123-3 摘要:Balin-Gauthier D, Delord JP, Rochaix P, Mallard V, Thomas F, Hennebelle I, Bugat R, Canal P, Allal C. In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different level of EGFR. Cancer Chemother Pharmacol. 2006 Jun;57(6):709–18. doi: 10.1007/s00280-005-0123-3. 参考文献:10.1186/1477-7819-9-70 摘要:Wayne MG, Narang R, Chauhdry A, Steele J. Hepatic actinomycosis mimicking an isolated tumor recurrence. World Journal of Surgical Oncology. 2011 Jul 11;9(1):70. doi: 10.1186/1477-7819-9-70. 摘要:Burney IA, Al-Moundhri MS. Major Advances in the Treatment of Cancer: What does a Non-Oncologist need to know Sultan Qaboos Univ Med J. 2008 Jul;8(2):137–48.