专利号:US-8703952-B2 优先权日:2008-12-12 标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates 发明人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID 权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD 摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.
专利号:US-8450365-B2 优先权日:2009-05-12 标 题 :Efficient synthesis of galanthamine 发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ 权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS 摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.
专利号:US-5002641-A 优先权日:1990-06-28 标题:Electrochemical synthesis of niacin and other N-heterocyclic compounds 发明人:TOOMEY JR JOSEPH E 权利人:REILLY IND INC 摘要:An electrochemical oxidation of a pi-deficient N-heterocyclic precursor compound having an oxidizable organic group attached by a carbon-to-carbon linkage. This precursor compound is at least sparingly water soluble. The preferred electro-oxidation is conducted at an effective anode and in a medium which consists essentially of water, carboxylic acid, and the precursor compound. Preferred are electro-oxidations of substituted pyridine and quinoline bases and a particularly preferred aspect provides a convenient electrochemical synthesis of niacin from 3-methylpyridine.
专利号:EP-0150883-B1 优先权日:1984-02-02 标题 :Process for preparing n-(dibenzyloxyphosphoryl)-cyanamide and processes using said compounds as intermediate for the synthesis of phosphagen substances 摘要:The invention relates to a process for preparing compounds of general formula: wherein R = Hydrogen, halogen, alkyl, nitro-group; said compounds, which are indicated hereinunder with the general term <> are useful as intermediates in the synthesis of phosphagen compounds such as phosphocreatine, phosphocreatinine and similar compounds. Such process is characterized in that dibenzyloxyphosphoryl chloride is reacted with cyanamide, N-(dibenzyloxyphosphoryl)-cyanamide being produced; this latter can react with substances provided with a primary or secondary amine function, to give the corresponding guanidinoderivatives; e.g., with a sarcosine derivative to give N-(dibenzyloxyphosphoryl)-creatine or N-(dibenzyloxyphosphoryl)-creatinine.
专利号:US-6251350-B1 优先权日:1999-06-21 标 题 :Process for the manufacture of thiophosphoryl chloride 发明人:APPLEGATE JACQUELINE M; NEWALLIS PETER E; PRASAD VIDYANATHA A 权利人:BAYER AG 摘要:The present invention relates to an improved process for the preparation of thiophosphoryl chloride which is useful as an intermediate for the synthesis of insecticidally active compounds. The improvement comprises the presence in the reaction mixture of a catalytic amount of a nitroxide free radical of the following general formula: n wherein R 1 , R 2 , R 3 and R 4 represent an alkyl group.
专利号:US-9493461-B2 优先权日:2013-02-07 标 题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C 发明人:DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; LAI ZHONG; NARGUND RAVI; MARCANTONIO KAREN; XIAO DONG; BROCKUNIER LINDA L; ZORN NICOLAS; DANG QUN; PENG XUANJIA; LI PENG 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要:Sheldon, R. A., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 632. 摘要:National Technical Information Service., OTS0571695 摘要:Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(83), 1982 摘要:K. Clarke and K. Rothwell. J. Chem. Soc. 1960, 1885. 摘要:National Fire Protection Association. Fire Protection Guide on Hazardous Materials. 7th ed. Boston, Mass.: National Fire Protection Association, 1978., p. 49-160