5-硝基异酞酸置于盐酸,乙醇,硫化氢,氨体系中,化学反应生成 5-氨基间苯二甲酸二甲酯 参考文献:Cohen; Mc Candlish,Journal Of The Chemical Society,1905,Vol. 87,P. 1265 标题:Cohen; Mc Candlish,Journal Of The Chemical Society,1905,Vol. 87,P. 1265
专利号:US-8895747-B2 优先权日:2009-07-27 标 题 :Method and substances for preparation of N-substituted pyridinium compounds 发明人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL 权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS 摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.
专利号:CN-116514673-A 优先权日:2023-05-10 标 题 :Synthesis of substituted anilines
专利号:US-5258407-A 优先权日:1991-12-31 标题 :3,4-disubstituted phenols-immunomodulating agents 发明人:WASHBURN WILLIAM N; LUSSIER BARBARA B; ILLIG CARL B; LATIMER LEE H 权利人:STERLING WINTHROP INC 摘要:Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: FORMULA I wherein Y is NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -OH; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety.
专利号:US-5466715-A 优先权日:1991-12-31 标题:3,4-disubstituted phenols-immunomodulating agents 发明人:WASHBURN WILLIAM N; LUSSIER BARBARA B; ILLIG CARL R; LATIMER LEE H 权利人:STERLING WINTHROP INC 摘要:Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: FORMULA I wherein Y is NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -OH; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety selected from the group consisting of substituted C1-C10 alkyl, C3-C16 cycloalkyl and 2,4-di-t-pentylphenyl.
专利号:CN-105237337-A 优先权日:2015-11-11 标题:Synthesis method of novel 5-[10-(9-carboxyanthracenyl)]-isophthalic acid
专利号:SU-1766914-A1 优先权日:1990-02-19 标题:Method of 2-chloro-5-(3@@@,5@@@-dicarbomethoxyonenylsulfamido)- nitrobenzene synthesis
参考文献:10.1007/978-1-62703-339-8_5 摘要:Crighton G. Methods of coagulation. Methods Mol Biol. 2013;992():73–83. doi: 10.1007/978-1-62703-339-8_5. 参考文献:10.1007/s10854-024-12749-4 摘要:Çavdar Ş, Oruç P, Eymur S, Tuğluoğlu N. Investigation of photosensitive and photodetector characteristics of n-TPA-IFA/p-Si heterojunction structure. J Mater Sci: Mater Electron. 2024 May;35(15). doi: 10.1007/s10854-024-12749-4. 参考文献:10.1007/s00044-024-03361-6 摘要:Cuffaro D, D’Antongiovanni V, Mangini C, Di Salvo C, Benvenuti L, Vandooren J, Macchia M, Antonioli L, Rossello A, Fornai M, Nuti E. Multivalent MMP-12 inhibitors as a valuable approach to counteract the intestinal epithelial barrier impairment and inflammation in an in vitro model mimicking intestinal high-fat exposure. Med Chem Res. 2024 Dec 21;34(3):571–82. doi: 10.1007/s00044-024-03361-6.