CAS: 942514-62-7; 4-[(4-Methyl-1-Piperazinyl)Methyl]-N-[4-Methyl-3-[[4-Methyl-6-(3-Pyridinyl)-2-Pyrimidinyl]Amino]-Phenyl]Benzamide

英文名称4-[(4-Methyl-1-Piperazinyl)Methyl]-N-[4-Methyl-3-[[4-Methyl-6-(3-Pyridinyl)-2-Pyrimidinyl]Amino]-Phenyl]Benzamide
中文名称伊马替尼杂质4
CAS编号942514-62-7
分子式:C30H33N7O分子量:507.63
产品CID: 1992042
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: QOOVAKAKHDRXIG-UHFFFAOYSA-N
1S/C30H33N7O/c1-21-6-11-26(18-27(21)34-30-32-22(2)17-28(35-30)25-5-4-12-31-19-25)33-29(38)24-9-7-23(8-10-24)20-37-15-13-36(3)14-16-37/h4-12,17-19H,13-16,20H2,1-3H3,(H,33,
计算化学: 氢键受体数7.0氢键供体数2.0可旋转键数7.0

物理性质

MSDS等安全信息

上下游产品

4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-6-methyl-2-pyrimidinyl)amino]-phenyl]benzamide 3-pyridylboronic acid 6-methyl-2-(2-methyl-5-nitrophenylamino)-pyrimidin-4-one 6-methyl-2-methylsulfanyl-3H-pyrimidin-4-one

合成工艺路线路线简述

1692-25-7 + 1451042-81-1 = 942514-62-7
反应条件:1.1 Reagents: Triethylamine Catalysts: Phosphorus(1+),Bromotri-1-Pyrrolidinyl-,(T-4)-,Hexafluorophosphate(1-) (1:1) Solvents: 1,4-Dioxane; 2 H,45 °C1.2 Catalysts: Dichlorobis(Triphenylphosphine)Palladium; 0.5 H,Rt1.3 Reagents: Sodium Carbonate Solvents: Water; 22 H,Reflux
标题:Intermediates For A Novel Process Of Preparing Imatinib And Related Tyrosine Kinase Inhibitors
参考文献:World Intellectual Property Organization]

106261-64-7 + 1032314-73-0 = 942514-62-7
反应条件:1.1 Solvents: Pyridine; 18 H,20 °C
标题:Preparation Of Pyrimidine-2-Amine Compositions Related To Wrapping Of Dehydrons
参考文献:World Intellectual Property Organization]

= 942514-62-7 [标题:Reaction Conditions
标题:Rational Drug Redesign To Overcome Drug Resistance In Cancer Therapy: Imatinib Moving Target
作者:Fernandez,Ariel; Sanguino,Angela; Peng,Zhenghong; Crespo,Alejandro; Ozturk,Eylem; Et Al
参考文献:Cancer Research 日期:2007 卷标:67(9) 页码:4028-4033

📜2-氨基-4-硝基甲苯置于盐酸,铁粉,氯化铵,三乙胺,Bromo-Tris(1-Pyrrolidinyl)Phosphonium Hexafluorophosphate体系中,用四氢呋喃,1,4-二氧六环,乙醇,水作为反应溶剂,化学反应 53.0H,反应生成伊马替尼杂质4
参考文献: Intermediates For A Novel Process Of Preparing Imatinib And Related Tyrosine Kinase Inhibitors[fr] Intermédiaires Pour Un Nouveau Procédé De Préparation D'Imatinib Et D'Inhibiteurs De Tyrosine Kinase Associés
标题: Intermediates For A Novel Process Of Preparing Imatinib And Related Tyrosine Kinase Inhibitors[fr] Intermédiaires Pour Un Nouveau Procédé De Préparation D'Imatinib Et D'Inhibiteurs De Tyrosine Kinase Associés