CAS: 932-22-9; 4,5-Dichloro-3(2H)-Pyridazinone

• 英文名称4,5-Dichloro-3(2H)-Pyridazinone
• 中文名称4,5-二氯-3-羟基哒嗪
• IUPAC名称4,5-dichloropyridazin-3(2H)-one
• 其它别名4,5-二氯-3(2H)-哒嗪酮4,5-二氯-3-哒嗪酮4,5-二氯哒嗪-3(2H)-酮; 4,5-Dichloro-3-Hydroxypyridazine
• CAS编号932-22-9
• MFCD编号:MFCD00051504
• EINECS号:629-394-8
• FDA UNII编号:8FQ8PU4SSS
• 分子式:C4H2Cl2N2O
• 分子量:164.98
• 产品CID: 1970624
• 产品分类有机原料→分子砌块→芳杂环类化合物→哒嗪类化合物

• 相似结构搜索
• 产品信息参考;;
• InChIKey: VJWXIRQLLGYIDI-UHFFFAOYSA-N
• InChI=1S/C4H2Cl2N2O/c5-2-1-7-8-4(9)3(2)6/h1H,(H,8,9)…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

物理性质

• 熔点204-206°C
• 沸点339.2°C at 760 mmHg
• 闪点159 °C
• 密度1.76±0.1 g/cm3(预测)
• pKa:8.39±0.60(预测)
• PSA:45.75
• LogP:1.0767
• 折射率1.611
• 蒸汽压2.46E-06 mmHg at 25 °C
• 溶解性DMSO (Slightly), Methanol (Slightly)
• 外观形态白色至黄色结晶粉末
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用作控制农业虫害和病原体.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别4(经口)
• 警示词Warning(警告)
• 危险描述H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H302 |吞咽有害.
• 防范说明P264-P270-P330-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi,Xn
• 安全声明26-36-37/39
• 危险类别码36/37/38-22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 57-56-7 + 766-40-5 = 932-22-9 [标题:Reaction Conditions
  标题:δα,β-Butenolides. Xii. Reactions Of Mucohalogen Acids With Amides And Sulfonamides
  作者:Dambeniece,I.; Karklina,A.; Petrova,M. V.; Gudriniece,E.
  参考文献:Latvijas Psr Zinatnu Akademijas Vestis 日期:1989 卷标:(5) 页码:563-9]
  
  766-40-5 = 932-22-9
  反应条件:1.1 Reagents: Hydrazine
  标题:Functionalization Of 4,5-Dichloropyridazin-3(2H)-One
  作者:Sung,Gi Hyeon; Kim,Bo Ram; Ryu,Ki Eun; Yoon,Yong-Jin
  参考文献:Journal Of The Korean Chemical Society 日期:2014 卷标:58(1) 页码:140-144]
  
  = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Ethanol,Water; 1 H,60 °C1.2 4 H,Reflux; Reflux -> Rt
  标题:Novel Formation Of 1,3-Oxazepine Heterocycles Via Palladium-Catalyzed Intramolecular Coupling Reaction
  作者:Ma,Chen; Liu,Shao-Jie; Xin,Liang; Falck,J. R.; Shin,Dong-Soo
  参考文献:Tetrahedron 日期:2006 卷标:62(38) 页码:9002-9009]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine,Sulfuric Acid; Heated
  标题:Design,Synthesis And Biological Activity Of 5-(Alkoxy)-3(2H)-Pyridazinone Derivatives
  作者:Ling,Yun; Li,Hong-Sen; Yang,Xin-Ling; Bao,Han; Qiu,Li-Hong; Et Al
  参考文献:Youji Huaxue 日期:2007 卷标:27(6) 页码:763-767]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine,Sulfuric Acid Solvents: Water; Heated
  标题:Study On The Synthesis And Bioactivity Of Pyridazinone Derivatives
  作者:Li,Hong-Sen; Ling,Yun; Guo,Yu-Lai; Yang,Xin-Ling; Chen,Fu-Heng
  参考文献:Youji Huaxue 日期:2005 卷标:25(2) 页码:204-207]
  
  766-40-5 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Water; 4 H,100 °C
  标题:Crystal Structure And Dft Calculations Of 4,5-Dichloropyridazin-3-(2H)-One
  作者:Silva,E. F. Jr.; Silva,D. L.; Santos,P. F. S. Jr.; Nascimento,I. J. S.; Silva,S. W. D.; Et Al
  参考文献:Journal Of Chemical And Pharmaceutical Research 日期:2016 卷标:8(1) 页码:279-286]
  
  766-40-5 = 932-22-9
  反应条件:1.1 Reagents: Hydrazine,Sulfuric Acid Solvents: Water; 12 H,100 °C
  标题:Access To 4-Alkylaminopyridazine Derivatives Via Nitrogen-Assisted Regioselective Pd-Catalyzed Reactions
  作者:Blaise,Emilie; Kummerle,Arthur E.; Hammoud,Hassan; De Araujo-Junior,Joao Xavier; Bihel,Frederic; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2014 卷标:79(21) 页码:10311-10322]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine,Sulfuric Acid; 100 °C
  标题:Study On The Synthesis And Bioactivity Of Pyridazinone Derivatives
  作者:Li,Hong-Sen; Zhao,Lin-Jing; Tang,Jia-Rong; Cheng,Yi-Zhe; Chen,Jie; Et Al
  参考文献:Huaxue Yanjiu Yu Yingyong 日期:2012 卷标:24(11) 页码:1741-1744]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Hydrazine Sulfate Catalysts: Sodium Acetate Solvents: Water; 2 H,Rt -> 100 °C
  标题:Thiadiazole Compounds As Pesticides And Their Preparation,Agricultural Compositions And Use In The Control Of Pests
  参考文献:China]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Hydrazine Sulfate Catalysts: Sodium Acetate Solvents: Water; Rt -> 100 °C; 2 H,80 - 100 °C
  标题:Oxadiazole-3(2H)-Pyridazinone Compounds As Insecticides And Their Preparation,Agrochemical Compositions And Use In The Control Of Insects
  参考文献:China]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Water; 2 H,80 - 100 °C
  标题:Bishydrazide Compound As Insecticide And Its Preparation
  参考文献:China]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Water; Rt -> 100 °C; 2 H,80 - 100 °C
  标题:Preparing Of Pyridazinone Compounds As Insecticides
  参考文献:China]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Hydrazine
  标题:Synthesis And Pharmacological Study Of A Series Of 3(2H)-Pyridazinones As Analgesic And Antiinflammatory Agents
  作者:Santagati,N. A.; Duro,F.; Caruso,A.; Trombadore,S.; Amico-Roxas,M.
  参考文献:Farmaco 日期:1985 卷标:40(12) 页码:921-9]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine,Dihydrochloride Solvents: Water; Reflux
  标题:Study On New 3-(2H)-Pyridazinones Derivatives
  作者:Li,Hong Sen; Zhao,Lin Jin; Tang,Jia Rong; Cheng,Yi Zhe; Chen,Jie; Et Al
  参考文献:Advanced Materials Research (Durnten-Zurich 日期:2012 卷标:524 页码:524-527]
  
  = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Ethanol,Water; 4 H,70 °C
  标题:Unconventional Site Selectivity In Palladium-Catalyzed Cross-Couplings Of Dichloroheteroarenes Under Ligand-Controlled And Ligand-Free Systems
  作者:Norman,Jacob P.; Larson,Nathaniel G.; Entz,Emily D.; Neufeldt,Sharon R.
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(11) 页码:7414-7421]
  
  57697-64-0 = 932-22-9
  反应条件:1.1 Reagents: Acetic Acid,Hydrazine Sulfate Solvents: Water
  标题:Synthesis And Biological Activity Of 5-(Acyl)Hydrazine-3(2H)-Pyridazinone
  作者:Ling,Yun; Chen,Haifeng; Liu,Jia; Yang,Xinling
  参考文献:Nongyaoxue Xuebao 日期:2009 卷标:11(1) 页码:25-30]
  
  949910-49-0 = 932-22-9
  反应条件:1.1 Reagents: Sodium Carbonate,Hydrazine Sulfate Solvents: Water; Rt -> Reflux; 1.5 H,Reflux; Cooled
  标题:Studies On Synthesis And Biological Activity Of Pyridazinone Derivatives As α1-Adrenoceptor Antagonist
  作者:Xi,Bao-Min; Jiang,Zhen-Zhou; Wang,Tao; Ni,Pei-Zhou
  参考文献:Youji Huaxue 日期:2006 卷标:26(11) 页码:1576-1583]
  
  766-40-5 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate (1:?) Solvents: Water; 4 H,Reflux
  标题:Pyridazinones As Glucokinase Activators And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Metabolic Disorders
  参考文献:World Intellectual Property Organization]
  
  766-40-5 = 932-22-9
  反应条件:1.1 Reagents: Sodium Acetate,Hydrazine Sulfate Solvents: Ethanol,Water; 1 H,Rt -> 60 °C1.2 4 H,Reflux
  标题:One-Pot Highly Regioselective Synthesis Of Indole-Fused Pyridazino[4,5-B][1,4]Benzoxazepin-4(3H)-Ones By A Smiles Rearrangement
  作者:Jiang,Xiaolei; Hu,Fangdong
  参考文献:Synlett 日期:2018 卷标:29(9) 页码:1207-1210]
  
  = 932-22-9 [标题:Reaction Conditions
  标题:Product Class 8: Pyridazines
  作者:Haider,N.; Holzer,W.
  参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:125-249

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