CAS: 875664-27-0; 2-Bromo-4-Fluoro-6-(Trifluoromethyl)Aniline

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4-fluoro-2-(trifluoromethyl)aniline 1-bromo-2-chloro-5-fluoro-3-(trifluoromethyl)benzene 1,2-dibromo-5-fluoro-3-(trifluoromethyl)benzene

2-氨基-5-氟三氟甲苯置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙腈 作为反应溶剂,化学反应 2.0H,以77.8%的收率获得产物2-氨基-3-溴-5-氟三氟甲苯
参考文献: Compounds And Compositions For Treating Conditions Associated With Nlrp Activity[fr] Composés Et Compositions Destinés Au Traitement D'états Pathologiques Associés à Une Activité Nlrp
标题: Compounds And Compositions For Treating Conditions Associated With Nlrp Activity[fr] Composés Et Compositions Destinés Au Traitement D'états Pathologiques Associés à Une Activité Nlrp
摘要:在一个方面,特色化合物aa的公式,或其药学上可接受的盐.在公式aa中显示的变量如索引中所定义.公式aa的化合物是nlrp3活性调节剂,因此可用于治疗代谢性疾病(例如2型糖尿病,动脉粥样硬化,肥胖或痛风),中枢神经系统疾病(例如阿尔茨海默病,多发性硬化症,肌萎缩性侧索硬化或帕金森病),肺部疾病(例如哮喘,慢性阻塞性肺疾病或肺部特发性纤维化),肝脏疾病(例如nash综合征,病毒性肝炎或肝硬化),胰腺疾病(例如急性胰腺炎或慢性胰腺炎),肾脏疾病(例如急性肾损伤或慢性肾损伤),肠道疾病(例如克罗恩病或溃疡性结肠炎),皮肤疾病(例如牛皮癣),肌肉骨骼疾病(例如硬皮病),血管障碍(例如巨细胞动脉炎),骨骼疾病(例如骨关节炎,骨质疏松症或骨质增生疾病),眼部疾病(例如青光眼或黄斑变性),病毒感染引起的疾病(例如hiv或艾滋病),自身免疫疾病(例如类风湿性关节炎,系统性红斑狼疮或自身免疫性甲状腺炎),癌症或衰老.

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.