CAS: 86604-74-2; 2-(Chloromethyl)-4-Methoxy-3-Methylpyridine Hydrochloride

该化合物是一种多用途的丙烯衍生物,通常用作制药和农用化学合成的关键中间体,其反应性氯甲基组为进一步功能化提供便利,使其对建设复杂的分子框架具有价值.甲氧基和甲基替代成分增强了其稳定性和影响电子特性,有助于选择性反应.该化合物由于纯度高且反应性强,对制备活性药物成分和精细化学品特别有用.其盐酸盐形式提高了极地溶剂的溶性,简化了下游加工程序.严格的质量控制确保了遵守工业标准,使其成为研究和工业应用的可靠选择.

英文名称2-(Chloromethyl)-4-Methoxy-3-Methylpyridine Hydrochloride
中文名称2-(氯甲基)-4-甲氧基-3-甲基吡啶盐酸盐
IUPAC名称2-(chloromethyl)-4-methoxy-3-methylpyridine hydrochloride
其它别名2-Chloromethyl-4-Methoxy-3-Methyl Pyridi Ne Hydrochloride (Iiaprazole Chloro; Ilaprazole Impurity Hcl; 2Chloromethyl-4-Methoxy-3-Methyl Pyrine Hydrochloride; Pyridine, 2-(Chloromethyl)-4-Methoxy-3-Methyl-, Hydrochloride; Ilaprazole Impurity Hcl (2-(Chloromethyl)-4-Methoxy-3-Methylpyridine Hcl); Rabeprazole Impurity 5 Hcl; Ilaprazole Impurity 32 Hcl; Ilaprazole Intermediate
CAS编号86604-74-2
MFCD编号:MFCD03425333
分子式:C8H11Cl2NO分子量:208.09
产品CID: 1868788
产品分类医药中间体

相似结构搜索
InChIKey: WHAGSNVVBXOIGQ-UHFFFAOYSA-N
InChI=1S/C8H10ClNO.ClH/c1-6-7(5-9)10-4-3-8(6)11-2;/h3-4H,5H2,1-2H3;1H
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H319
防范说明P305+P351+P338
UN编号3261

上下游产品

CAS号86604-77-5 4-甲氧基-3-甲基-2-吡啶甲醇 | CAS号37699-43-7 2,3-二甲基-4-硝基吡啶-N-氧化物 | CAS号102625-96-7 4-methoxy-2,3-d... | CAS号102625-98-9 Acetic acid 4-m... | CAS号22710-07-2 2,3-二甲基吡啶氮氧化物 | CAS号59886-90-7 2,3-二甲基-4-氯吡啶-N-氧化物 | CAS号253345-81-2 (4-methoxy-3-me... | CAS号102804-82-0 2-{[(4-甲氧基-3-甲基... | CAS号102804-77-3 2-[[(4-甲氧基-3-甲基... | CAS号86604-69-5 2-[(4-methoxy-3... | CAS号97966-86-4 2,2-difluoro-6-...

合成工艺路线路线简述

合成目标产物 2-(Chloromethyl)-4-Methoxy-3-Methylpyridine Hydrochloride 主要起始原料 4-Nitro-2,3-Lutidine-N-Oxide
102625-96-7 = 86604-74-2
反应条件:1.1 Reagents: Acetic Acid Solvents: Methanol,Toluene2.1 Reagents: Sodium Hydroxide Solvents: Methanol2.2 Reagents: Hydrochloric Acid3.1 Reagents: Thionyl Chloride
标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
作者:Sharada,L. N.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

59886-90-7 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide2.1 Reagents: Acetic Acid Solvents: Methanol,Toluene3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane3.2 Reagents: Hydrochloric Acid4.1 Reagents: Thionyl Chloride
标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
作者:Sharada,L. N.; Et Al
参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

37699-43-7 = 86604-74-2
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Dimethylformamide,Dichloromethane; 2 H,5 °C; 5 °C -> 25 °C; 12 H,25 °C1.2 Reagents: Sodium Carbonate Solvents: Water; 25 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dimethyl Sulfoxide; 1 H,60 °C2.2 1 H,60 °C; 3 H,60 °C2.3 Reagents: Water3.1 5 H,120 °C4.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,25 °C5.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,25 °C
标题:Identification And Synthesis Of Potential Impurities Of Rabeprazole Sodium
作者:Pingili,R. Reddy; Et Al
参考文献:Pharmazie 日期:2005 卷标:60(11) 页码:814-818]

86604-77-5 = 86604-74-2
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,25 °C
标题:Identification And Synthesis Of Potential Impurities Of Rabeprazole Sodium
作者:Pingili,R. Reddy; Et Al
参考文献:Pharmazie 日期:2005 卷标:60(11) 页码:814-818]

253345-81-2 = 86604-74-2
反应条件:1.1 Reagents: Thionyl Chloride
标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
作者:Sharada,L. N.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

253345-81-2 = 86604-74-2
反应条件:1.1 Reagents: Thionyl Chloride
标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
作者:Sharada,L. N.; Et Al
参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

102625-98-9 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol1.2 Reagents: Hydrochloric Acid2.1 Reagents: Thionyl Chloride
标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
作者:Sharada,L. N.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

102625-98-9 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane1.2 Reagents: Hydrochloric Acid2.1 Reagents: Thionyl Chloride
标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
作者:Sharada,L. N.; Et Al
参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

102625-98-9 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,25 °C2.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,25 °C
标题:Identification And Synthesis Of Potential Impurities Of Rabeprazole Sodium
作者:Pingili,R. Reddy; Et Al
参考文献:Pharmazie 日期:2005 卷标:60(11) 页码:814-818]

102625-96-7 = 86604-74-2
反应条件:1.1 Reagents: Acetic Acid Solvents: Methanol,Toluene2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane2.2 Reagents: Hydrochloric Acid3.1 Reagents: Thionyl Chloride
标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
作者:Sharada,L. N.; Et Al
参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

102625-96-7 = 86604-74-2
反应条件:1.1 5 H,120 °C2.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,25 °C3.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,25 °C
标题:Identification And Synthesis Of Potential Impurities Of Rabeprazole Sodium
作者:Pingili,R. Reddy; Et Al
参考文献:Pharmazie 日期:2005 卷标:60(11) 页码:814-818]

59886-90-7 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide2.1 Reagents: Acetic Acid Solvents: Methanol,Toluene3.1 Reagents: Sodium Hydroxide Solvents: Methanol3.2 Reagents: Hydrochloric Acid4.1 Reagents: Thionyl Chloride
标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
作者:Sharada,L. N.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

59886-90-7 = 86604-74-2
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dimethyl Sulfoxide; 1 H,60 °C1.2 1 H,60 °C; 3 H,60 °C1.3 Reagents: Water2.1 5 H,120 °C3.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,25 °C4.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,25 °C
标题:Identification And Synthesis Of Potential Impurities Of Rabeprazole Sodium
作者:Pingili,R. Reddy; Et Al
参考文献:Pharmazie 日期:2005 卷标:60(11) 页码:814-818]

37699-43-7 = 86604-74-2
反应条件:1.1 Reagents: Phosphorus Oxychloride; 3 - 4 H,Reflux2.1 Reagents: Sodium Hydroxide3.1 Reagents: Acetic Acid Solvents: Methanol,Toluene4.1 Reagents: Sodium Hydroxide Solvents: Methanol4.2 Reagents: Hydrochloric Acid5.1 Reagents: Thionyl Chloride
标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
作者:Sharada,L. N.; Et Al
参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

37699-43-7 = 86604-74-2
反应条件:1.1 Reagents: Phosphorus Oxychloride; 3 - 4 H,Reflux2.1 Reagents: Sodium Hydroxide3.1 Reagents: Acetic Acid Solvents: Methanol,Toluene4.1 Reagents: Sodium Hydroxide Solvents: Methanol,Dichloromethane4.2 Reagents: Hydrochloric Acid5.1 Reagents: Thionyl Chloride
标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
作者:Sharada,L. N.; Et Al
参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112

📜2,3-二甲基-4-甲氧基吡啶氮氧化物置于氯化亚砜,溶剂黄146,Sodium Hydroxide体系中,用甲醇,甲苯作为反应溶剂,化学反应生成 2-(氯甲基)-4-甲氧基-3-甲基吡啶盐酸盐
参考文献:Diversified Synthesis Of Novel Quinoline And Dibenzo Thiazepine Derivatives Using Known Active Intermediates
标题:Diversified Synthesis Of Novel Quinoline And Dibenzo Thiazepine Derivatives Using Known Active Intermediates
摘要:新型药物的开发以控制常规药物治疗中抗药性感染是当今的需求.通过趋同合成法开发了少量与抗溃疡相关的衍生物.成功合成的衍生物包括二苯并噻嗪啶-吡啶(sln11-Sln15)和苯并咪唑-氢奎宁基衍生物(sln16-Sln20).在最终步骤中采用了微波,超声和常规技术进行耦合.有效的技术被识别为超声技术,主要体现在时间和产率上.报告的化合物通过元素分析和谱学研究(如1H,13C NMR和质谱)进行了结构表征.
DOI:10.14233/ajchem.2013.14818