6968-28-1 = 86-90-8 反应条件:1.1 Reagents: Acetic Anhydride; 2 H,140 °C 标题:Design,Synthesis And Structure-Activity Relationship Studies Of Morpholino-1H-Phenalene Derivatives That Antagonize Mcl-1/bcl-2 作者:Li,Xiangqian; Et Al 参考文献:Bioorganic & Medicinal Chemistry 日期:2014 卷标:22(21) 页码:5738-5746]
106701-82-0 = 86-90-8 反应条件:1.1 Reagents: Thionyl Chloride 标题:Conformationally Restricted Analogs Of Remoxipride As Potential Antipsychotic Agents 作者:Norman,Mark H.; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:1993 卷标:36(22) 页码:3417-23]
13209-32-0 = 86-90-8 反应条件:1.1 Reagents: Oxygen Catalysts: Dipropylene Glycol Dimethyl Ether; Rt; 10 H,80 °C 标题:Green And Efficient: Oxidation Of Aldehydes To Carboxylic Acids And Acid Anhydrides With Air 作者:Liu,Kai-Jian; Et Al 参考文献:Acs Sustainable Chemistry & Engineering 日期:2018 卷标:6(4) 页码:4916-4921]
= 86-90-8 反应条件:1.1 Reagents: Sodium Hydroxide,Bromine Solvents: Water; 12 H,90 °C; 90 °C -> 0 °C1.2 Reagents: Thionyl Chloride; 0 °C -> Reflux; 5 H,Reflux1.3 Solvents: Dichloromethane; 2 H,Rt 标题:Development Of Dihydroxyphenyl Sulfonylisoindoline Derivatives As Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors 作者:Tso,Shih-Chia; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(3) 页码:1142-1150
专利号:US-11434217-B2 优先权日:2017-12-29 标 题 :Method for synthesis of lobaric acid and analog thereof 发明人:YIM JOUNG HAN; KIM IL-CHAN; HAN SE JONG; YOUN UI JOUNG; LEE HONG KUM; LEE JUN HYUCK; KIM TAI KYOUNG; YEO KWON JOO 权利人:KOREA INST OCEAN SCI & TECH; KOREA INSTITUTE OF OCEAN SCIENCE AND TECH 摘要:The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.
专利号:US-11920040-B2 优先权日:2018-05-29 标 题 :Carborhodamine compounds and methods of preparation thereof 发明人:LUKHTANOV EUGENY A 权利人:ELITECHGROUP MDX LLC 摘要:The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
专利号:US-5322954-A 优先权日:1993-05-28 标 题 :Synthesis of 4-substituted phthalic anhydrides 发明人:SEPER KARL W; STULTS JEFFREY S; OLSEN GARY H 权利人:OCCIDENTAL CHEM CO 摘要:Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula ##STR1## The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula ##STR2## The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula ##STR3## where R 1 , R 2 , and R 4 are preferably H and R 3 is preferably Cl or F.
专利号:US-2011263540-A1 优先权日:2008-07-25 标题 :Small-molecule inhibitors of protein synthesis inactivating toxins 发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.
专利号:US-2016223559-A1 优先权日:2015-02-02 标题:Tetrazine-containing compounds and synthetic methods thereof 发明人:DEVARAJ NEAL K; WU HAOXING; YANG JUN 权利人:UNIV CALIFORNIA 摘要:Described herein are tetrazine derivatives and efficient synthetic methods of synthesis thereof using elimination-Heck cascade reaction. Provided herein is the synthesis of conjugated tetrazines from the tetrazine derivatives. Also provided herein are methods of use of the conjugated tetrazines as fluorogenic probes for live-cell imaging.
专利号:US-RE49222-E 优先权日:2013-10-02 标题 :Fluorine-containing complex compound, and production method for fluorine-containing organic compound employing same 发明人:ADACHI KENJI; SHIBANUMA TAKASHI; NAGAI TAKABUMI; OGOSHI SENSUKE; OHASHI MASATO 权利人:DAIKIN IND LTD; UNIV OSAKA 摘要:An object of the present invention is to enable the synthesis of various fluorine-containing compounds having an organic group at both terminals of their tetrafluoroethylene structure (—CF 2 —CF 2 —). The present invention provides a fluorine-containing complex compound includingn a fluorine-containing organic metal compound represented by formula (1a):n nR 1 —CF 2 —CF 2 -M 1   (1a)n nwherein M 1 is a metal selected from the group consisting of copper, zinc, nickel, iron, cobalt, and tin; and R 1 represents an organic group, andn at least one ligand selected from the group consisting of pyridine ring-containing compounds and phosphines.
参考文献:10.1055/s-0033-1341263 摘要:Synthesis of a Dipeptidyl Peptidase-4 Inhibitor. Synfacts. 2014 May 16;10(06):0554. doi: 10.1055/s-0033-1341263. 参考文献:10.1007/s10570-024-05833-9 摘要:Park YK, Ryu S, Kim M, Lee JJ, Lee W. Colorimetric cotton sensors fabricated by ultraviolet photografting for acidic gas detection: optimization and characterization. Cellulose. 2024 Mar 21;31(6):3821–42. doi: 10.1007/s10570-024-05833-9. 参考文献:10.1007/s10118-025-3280-3 摘要:Niu M, Hu C, Pang X, Chen X. 4-Bromophthalic Anhydride-based Polyesters as a Versatile Modified Platform. Chin J Polym Sci. 2025 Feb 24;43(6):958–63. doi: 10.1007/s10118-025-3280-3. 参考文献:10.1007/s10118-025-3383-x 摘要:Tao Y, Li Z. Special Topic: Depolymerizable Polymers. Chin J Polym Sci. 2025 Jun;43(6):875. doi: 10.1007/s10118-025-3383-x.