CAS: 74470-23-8; 2-(Methylthio)Nicotinic Acid
该化合物是一种有机化合物,属于硝酸类,是的衍生物;该化合物的特性是附于环第二碳的甲基硫基(-S-CH3),以及位于的丙烯酸第六位置的氨基酸功能组(-COOH),其特点是白到白晶线外,在水和酒精等极地溶剂中可溶解.甲基硫酸和氨基酸组的存在都有助于其独特的化学再活性和潜在的生物活动. 2-(甲基乙基硫酸)可显示出抗氧化剂活动等特性,并可能对制药研究具有兴趣,特别是针对各种生物途径的化合物的开发.与许多有机化合物一样,处理应谨慎进行,遵守适当的安全议定书,以减少与使用该物质有关的任何潜在危害.
- 英文名称2-(Methylthio)Nicotinic Acid
- 中文名称2-(甲硫基)烟酸
- IUPAC名称2-(methylthio)nicotinic acid
- 其它别名2-甲硫基烟酸; 2-Methylsulfanylpyridine-3-Carboxylic Acid
- CAS编号74470-23-8
- MFCD编号:MFCD00010101
- EINECS号:628-977-4
- 分子式:C7H7NO2S分子量:169.2
- 产品CID: 1734736
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: COPSJQVPEUUOKY-UHFFFAOYSA-N
- InChI=1S/C7H7NO2S/c1-11-6-5(7(9)10)3-2-4-8-6/h2-4H,1H3,(H,9,10)
- 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0
相似化合物
219766-02-6 62658-91-7 62658-92-8物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号38521-46-9 2-巯基烟酸 | CAS号74-88-4 碘甲烷 | CAS号91540-68-0 3-Pyridinecarbo... | CAS号2942-59-8 2-氯烟酸 | CAS号74405-28-0 2-methylthiopyr... | CAS号97936-43-1 2-(甲硫基)烟酰氯 | CAS号62658-90-6 (2-(甲基硫代)吡啶-3-基)甲醇 | CAS号62658-91-7 methyl 2-methyl... | CAS号62658-92-8 2-(甲基硫代)烟醛合成工艺路线路线简述
📜2-氯烟酸置于氢氧化钾体系中,用 乙醇,水,二甲基亚砜 作为反应溶剂,化学反应 6.5H,反应生成 2-甲硫基烟酸
参考文献:Monge; Martinez-Merino; Cenarruzabeitia,European Journal Of Medicinal Chemistry,1985,Vol. 20,# 1,P. 61-66
标题:Monge; Martinez-Merino; Cenarruzabeitia,European Journal Of Medicinal Chemistry,1985,Vol. 20,# 1,P. 61-66
海关参考信息
- 2905110000-甲醇
2912110000-甲醛
2915110000-甲酸
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8754237-B2
优先权日:2006-02-14
标题:Bifunctional histone deacetylase inhibitors
发明人：BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L
权利人:BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L; HARVARD COLLEGE; DANA FARBER CANCER INST INC
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
专利号:US-8304451-B2
优先权日:2006-05-03
标题 :Histone deacetylase and tubulin deacetylase inhibitors
发明人：MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT
权利人:MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT; HARVARD COLLEGE; DANA FARBER CANCER INST INC
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—“isotubacinâ€? class and “isoisotubacinâ€? class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
专利号:US-8178579-B2
优先权日:2001-05-09
标 题:Dioxanes and uses thereof
发明人：SCHREIBER STUART L; STERNSON SCOTT M; WONG JASON C; GROZINGER CHRISTINA M; HAGGARTY STEPHEN J; KOELLER KATHRYN M
权利人:SCHREIBER STUART L; STERNSON SCOTT M; WONG JASON C; GROZINGER CHRISTINA M; HAGGARTY STEPHEN J; KOELLER KATHRYN M; HARVARD COLLEGE
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): n nand pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.
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📌 第三方产品分析报告
主要参考文献
参考标题:α-Heteroarylation Of Thioethers Via Photoredox And Weak Brønsted Base Catalysis作者:Edwin Alfonzo,Sudhir M. Hande |发布日期:2021.8.6
摘要:Thioethers To α-Thio Alkyl Radicals And Their Addition To N-Methoxyheteroarenium Salts For The Redox-Neutral Synthesis Of α-Heteroaromatic Thioethers. Studies Are Consistent With A Two-Step Activation Mechanism, Where Oxidation Of Thioethers To Sulfide Radical Cations By A Photoredox Catalyst Is Followed By α-C-H Deprotonation By A Weak Brønsted Base Catalyst To Afford α-Thio Alkyl Radicals. Further,
合成参考文献
参考文献:10.1055/a-1731-3852
摘要:Tang Y, Yu B. A Mild Heteroatom (O-, N-, and S-) Methylation Protocol Using Trimethyl Phosphate (TMP)–Ca(OH)2Combination. Synthesis. 2022 Mar 03;54(10):2373–90. doi: 10.1055/a-1731-3852.
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