📜苄基甲基硫醚置于氨,Potassium Amide体系中,化学反应生成 2-甲苯基甲硫醇 参考文献:Rearrangement Of Benzyl Sulfides To Mercaptans And Of Sulfonium Ions To Sulfides Involving The Aromatic Ring By Alkali Amides1,2 标题:Rearrangement Of Benzyl Sulfides To Mercaptans And Of Sulfonium Ions To Sulfides Involving The Aromatic Ring By Alkali Amides1,2 摘要: DOI:10.1021/ja01107A032
专利号:US-5331096-A 优先权日:1992-04-01 标题 :2- and 3-sulfur derivatives of 1,5-iminosugars 发明人:KOSZYK FRANCIS J; MUELLER RICHARD A 权利人:SEARLE & CO 摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
专利号:US-5342951-A 优先权日:1992-04-01 标题:2- and 3-sulfur derivatives of 1,5-iminosugars 发明人:KOSZYK FRANCIS J; MUELLER RICHARD A 权利人:SEARLE & CO 摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
专利号:US-5268482-A 优先权日:1992-04-01 标 题:2- and 3-sulfur derivatives of 1,5-iminosugars 发明人:KOSZYK FRANCIS J; MUELLER RICHARD A 权利人:SEARLE & CO 摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
专利号:CN-115010632-A 优先权日:2022-07-07 标 题 :Green synthesis method of thiol compounds
专利号:US-12037358-B2 优先权日:2016-08-23 标 题 :Compositions comprising reversibly modified oligonucleotides and uses thereof 发明人:WANG WEIMIN; KRISHNAMURTHY VENKATA 权利人:DICERNA PHARMACEUTICALS INC 摘要:Disclosed herein are glutathione-sensitive oligonucleotides and methods of using the same. Any oligonucleotide of interest may be modified with a glutathione-sensitive moiety, including oligonucleotides used for in vivo delivery, such as nucleic acid inhibitor molecules. Typically, the glutathione-sensitive moiety is used to reversibly modify the 2′-carbon of a sugar moiety in one or more nucleotides in the oligonucleotide, although other carbon positions may also be modified with the glutathione-sensitive moiety. Also disclosed are glutathione-sensitive nucleotide and nucleoside monomers, including glutathione-sensitive nucleoside phosphoramidites that can be used, for example, in standard oligonucleotide synthesis methods. In addition, glutathione-sensitive nucleotide and nucleoside monomers without a phosphoramidite can be used therapeutically, for example, as anti-viral agents.
专利号:CN-115010632-B 优先权日:2022-07-07 标 题:Green Synthesis Method of Thiol Compounds