CAS: 7341-24-4; 2-Methylbenzylmercaptan

该化合物是一种含有硫磺的芳香化合物,含有分子式C8H10S.该硫醇衍生物具有甲基替代苯环,与甲烷硫醇组结合,具有明显的回活动性和气味特性.有机合成中通常使用该化合物,因其具有引入硫功能的能力,因此它是医药,农用化学品和特殊化学品的一个构件.该化合物的稳定性和与各种反应条件的兼容性,使它成为热循环和金属调和化学中有价值的中间体.其强健的,光质的香味也用于气味和芳香配方. 妥善处理由于其挥发性和对氧化的潜在敏感性,是不可或缺的.

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[(methylthio)methyl]-benzene 2-methylbenzyl bromide thiophen1,3-Dihydrobenzothiophen o-xylene benzene1-methyl-2-(methylthio)methylbenzene ethyl 2-((2-methylbenzyl)thio)acetate bis(2-methylbenzyl) sulfide ethyl 2-(2-methylphenyl)acetate

合成工艺路线路线简述

    📜苄基甲基硫醚置于氨,Potassium Amide体系中,化学反应生成 2-甲苯基甲硫醇
    参考文献:Rearrangement Of Benzyl Sulfides To Mercaptans And Of Sulfonium Ions To Sulfides Involving The Aromatic Ring By Alkali Amides1,2
    标题:Rearrangement Of Benzyl Sulfides To Mercaptans And Of Sulfonium Ions To Sulfides Involving The Aromatic Ring By Alkali Amides1,2
    摘要:
    DOI:10.1021/ja01107A032

    海关参考信息

    专利信息


    专利号:US-5331096-A
    优先权日:1992-04-01
    标题 :2- and 3-sulfur derivatives of 1,5-iminosugars
    发明人:KOSZYK FRANCIS J; MUELLER RICHARD A
    权利人:SEARLE & CO
    摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

    专利号:US-5342951-A
    优先权日:1992-04-01
    标题:2- and 3-sulfur derivatives of 1,5-iminosugars
    发明人:KOSZYK FRANCIS J; MUELLER RICHARD A
    权利人:SEARLE & CO
    摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

    专利号:US-5268482-A
    优先权日:1992-04-01
    标 题:2- and 3-sulfur derivatives of 1,5-iminosugars
    发明人:KOSZYK FRANCIS J; MUELLER RICHARD A
    权利人:SEARLE & CO
    摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

    专利号:CN-115010632-A
    优先权日:2022-07-07
    标 题 :Green synthesis method of thiol compounds

    专利号:US-12037358-B2
    优先权日:2016-08-23
    标 题 :Compositions comprising reversibly modified oligonucleotides and uses thereof
    发明人:WANG WEIMIN; KRISHNAMURTHY VENKATA
    权利人:DICERNA PHARMACEUTICALS INC
    摘要:Disclosed herein are glutathione-sensitive oligonucleotides and methods of using the same. Any oligonucleotide of interest may be modified with a glutathione-sensitive moiety, including oligonucleotides used for in vivo delivery, such as nucleic acid inhibitor molecules. Typically, the glutathione-sensitive moiety is used to reversibly modify the 2′-carbon of a sugar moiety in one or more nucleotides in the oligonucleotide, although other carbon positions may also be modified with the glutathione-sensitive moiety. Also disclosed are glutathione-sensitive nucleotide and nucleoside monomers, including glutathione-sensitive nucleoside phosphoramidites that can be used, for example, in standard oligonucleotide synthesis methods. In addition, glutathione-sensitive nucleotide and nucleoside monomers without a phosphoramidite can be used therapeutically, for example, as anti-viral agents.

    专利号:CN-115010632-B
    优先权日:2022-07-07
    标 题:Green Synthesis Method of Thiol Compounds

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Grimmer, J.; Krieg, S.-C.; Manolikakes, G., Science of Synthesis Knowledge Updates, (2021) 1, 219.
    摘要:Kwiatkowska, M.; Kiełbasiński, P., Science of Synthesis: Knowledge Updates, (2024) 3, 421.
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