CAS: 71811-26-2; Benzyl (1,3-Dihydroxypropan-2-yl)Carbamate

该化合物是一个有机化合物,其特征为碳酸盐功能组,该组与苯基甲基和氢氧乙基侧链有关,该组通常看起来像白色的白色和非白色固体,由于存在可从事氢联结的氢氧基组,在极地溶剂中可以溶解.其结构表明药物或生物化学试剂中的潜在应用,特别是由于存在水氧甲基和氢氧组,可能会增强再活性或溶性.该组可能展示生物活动,使其对药用化学具有兴趣.然而,有关其毒性,稳定性和再活性的具体数据需要通过经验研究作进一步调查.与许多有机化合物一样,应当注意到适当的处理和安全防范措施,特别是在实验室环境中.

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上下游产品

benzyl chloroformate serinol (R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester(R)-2-N-(benzyloxycarbonyl)serinol monovalerate 2-benzyloxycarbonylaminopropenal H-fluoren-9-yl]-butyl}-2λ5-[1,3,2]dioxaphosphinan-5-yl)-carbamic acid benzyl ester(2-oxo-2-{4-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-2λ5-[1,3,2]dioxaphosphinan-5-yl)-carbamic acid benzyl ester 2-carbobenzyloxyamino-1,3-di-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)propane

合成工艺路线路线简述

    📜(2-Trimethylsilanyloxy-1-Trimethylsilanyloxymethyl-Ethyl)-Carbamic Acid Benzyl Ester置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 N-Cbz-2-氨基-1,3-丙二醇
    参考文献:5-Carboxamido-1,3,2-Dioxaphosphorinanes,Potent Inhibitors Of Mtp
    标题:5-Carboxamido-1,3,2-Dioxaphosphorinanes,Potent Inhibitors Of Mtp
    摘要:5-Carboxamido-1,3,2-Dioxaphosphorinanes Have Been Identified As Potent Inhibitors Of Microsomal Triglyceride-Transfer Protein. The 1,3,2-Dioxaphosphorine Functionality Acted As A Neutral And Stable Replacement For Piperidine And Piperidine N-Oxide. (C) 2004 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmcl.2004.07.069

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    专利信息


    专利号:US-5585252-A
    优先权日:1988-08-30
    标 题 :Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
    发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILIAM J
    权利人:SEARLE & CO
    摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

    专利号:US-5106750-A
    优先权日:1988-08-30
    标 题:Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
    发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILLIAM J; BABIAK KEVIN A; DYGOS JOHN H; NG JOHN S
    权利人:SEARLE & CO
    摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

    专利号:DE-68929190-T2
    优先权日:1988-08-30
    标 题:Enantio- and regioselective synthesis of organic compounds with enol esters as irreversible transacylation reagents

    专利号:JP-2843606-B2
    优先权日:1988-08-30
    标题 :Enantio- and regio-selective synthesis of organic compounds using enol esters as irreversible acyl transfer reagents

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    合成参考文献


    参考文献:10.1007/978-94-010-9124-4_15
    摘要:Wong CH. Aldolases in Organic Synthesis. 1990. In: Biocatalysis.
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