CAS: 6304-27-4; N,N-Dimethyl-2-Pyridin-2-Ylethanamine
该化合物是一种多用途有机化合物,其成分包括和三级地雷功能组,其结构使各种应用成为协调化学中的一流应用,由于其发泡特性,有助于金属复合物的稳定.二甲基氨基乙基副链会提高极地溶剂的溶解性,使其在催化系统和合成有机反应中有用.此外,其基本性和电子施食特性对制药中间体和精细化学合成都有利.该化合物在标准条件下的稳定性和与一系列试剂的兼容性进一步有助于其在研究和工业过程中的效用.
- 英文名称N,N-Dimethyl-2-Pyridin-2-Ylethanamine
- 中文名称2-(2-二甲基氨基乙基)吡啶
- IUPAC名称N,N-dimethyl-2-pyridin-2-ylethanamine
- 其它别名Pyridine,2-[2-(dimethylamino)ethyl]- (6CI,7CI,8CI); 2-(2-Dimethylaminoethyl)pyridine; 2-[b-(Dimethylamino)ethyl]pyridine; N,N-Dimethyl-2-pyridineethylamine; Y-G 15
- CAS编号6304-27-4
- MFCD编号:MFCD00023546
- EINECS号:228-608-3
- FDA UNII编号:WY6PA2X446
- 分子式:C9H14N2分子量:150.22
- 产品CID: 1611582
- 产品分类医药中间体 → 吡啶类化合物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号2706-56-1 2-(2-氨乙基)吡啶 | CAS号50-00-0 甲醛 | CAS号1738-25-6 3-(二甲基氨基)丙腈 | CAS号74-86-2 乙炔 | CAS号100-69-6 2-乙烯基吡啶 | CAS号124-40-3 二甲胺 | CAS号1945-84-2 2-乙炔基吡啶 | CAS号506-59-2 盐酸二甲胺 | CAS号109-06-8 2-甲基吡啶 | CAS号30354-18-8 N,N-二甲基亚甲蓝 | CAS号5638-76-6 倍他司汀 | CAS号54765-14-9 2-乙醛基吡啶 | CAS号124-40-3 二甲胺 | CAS号60717-49-9 二甲基-(2-哌啶-2-基-乙基)-胺合成工艺路线路线简述
📜2-氯甲基吡啶置于cesium Fluoride,Potassium Iodide体系中,用 N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 50.0H,反应生成 2-(2-二甲基氨基乙基)吡啶
参考文献:Maeda,Yasuhiro; Shirai,Naohiro; Sato,Yoshiro,Journal Of The Chemical Society. Perkin Transactions I,1994,# 4,P. 393-398
标题:Maeda,Yasuhiro; Shirai,Naohiro; Sato,Yoshiro,Journal Of The Chemical Society. Perkin Transactions I,1994,# 4,P. 393-398
海关参考信息
- 2933310010-吡啶
2921199090-其他无环单胺
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8754237-B2
优先权日:2006-02-14
标题:Bifunctional histone deacetylase inhibitors
发明人：BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L
权利人:BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L; HARVARD COLLEGE; DANA FARBER CANCER INST INC
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
专利号:US-8304451-B2
优先权日:2006-05-03
标题 :Histone deacetylase and tubulin deacetylase inhibitors
发明人：MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT
权利人:MAZITSCHEK RALPH; KWIATKOWSKI NICHOLAS PAUL; BRADNER JAMES ELLIOT; HARVARD COLLEGE; DANA FARBER CANCER INST INC
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—“isotubacinâ€? class and “isoisotubacinâ€? class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:R. B. Barlow and J. T. Hamilton. Brit. J. Pharmacol. 18, 510 (1962).
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