CAS: 598-23-2; 3-Methyl-1-Butyne

该化合物是具有分子式C5H8的终端烷,这种无色,挥发性液体的特征是其在终端碳中的三联结,使其成为有机合成中的宝贵构件.其结构特征是处于三点的甲基组,这影响其在选择性变异中的回动.该化合物在Sonogashira的联动反应,金属-烷复合形成以及作为药物和特殊化学品的前体方面特别有用.其相对较低的沸点(38-40°C)有利于易于处理和净化.终端烷功能使得能够高效点击化学应用,而分支结构有助于反应路径中的消毒效应.适当的处理需要注意其易燃性和潜在过氧化形成.

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ECHA物质ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    📜3-甲基-1,2-丁二烯 反应生成 3-甲基-1-丁炔
    参考文献:Slobodin,Zhurnal Obshchei Khimii,1934,Vol. 4,P. 781
    标题:Slobodin,Zhurnal Obshchei Khimii,1934,Vol. 4,P. 781

    海关参考信息

    专利信息


    专利号:US-8273790-B2
    优先权日:2005-01-14
    标 题:Exo-selective synthesis of himbacine analogs
    发明人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
    权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
    摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

    专利号:US-11891351-B2
    优先权日:2020-03-20
    标 题 :Synthesis of capsaicin derivatives
    发明人:LAGER ERIK
    权利人:AXICHEM AS
    摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

    专利号:US-9126995-B2
    优先权日:2011-11-08
    标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
    发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
    权利人:NISSAN CHEMICAL IND LTD
    摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

    专利号:WO-03031376-A1
    优先权日:2001-10-12
    标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
    发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

    专利号:US-2003162992-A1
    优先权日:2001-12-14
    标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
    发明人:WATANABE KYOICHI A; DU JINFA
    摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

    专利号:US-11999757-B2
    优先权日:2017-11-01
    标 题:Synthesis of boronate ester derivatives and uses thereof
    发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
    权利人:MELINTA SUBSIDIARY CORP
    摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Negishi, E.; Wang, G., Science of Synthesis, (2010) 47, 978.
    摘要:Batrice, R. J.; Karmel, I.-S. R.; Eisen, M. S., Science of Synthesis Knowledge Updates, (2012) 4, 121.
    摘要:Batrice, R. J.; Karmel, I.-S. R.; Eisen, M. S., Science of Synthesis Knowledge Updates, (2012) 4, 162.
    摘要:Batrice, R. J.; Karmel, I.-S. R.; Eisen, M. S., Science of Synthesis Knowledge Updates, (2012) 4, 200.
    摘要:Batrice, R. J.; Karmel, I.-S. R.; Eisen, M. S., Science of Synthesis Knowledge Updates, (2012) 4, 119.
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