CAS: 59-46-1; Procaine

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CAS号38973-67-0 2-(diethylamino... | CAS号99-77-4 对硝基苯甲酸乙酯 | CAS号100-37-8 二乙氨基乙醇 | CAS号619-45-4 4-氨基苯甲酸甲酯 | CAS号13456-39-8 2-diethylaminoe... | CAS号94-09-7 对氨基苯甲酸乙酯 | CAS号100-35-6 N,N-二乙基氯乙胺 | CAS号122-04-3 对硝基苯甲酰氯 | CAS号869-24-9 2-二乙氨基氯乙烷盐酸盐 | CAS号150-13-0 对氨基苯甲酸 | CAS号54-35-3 普鲁卡因青霉素 | CAS号21033-42-1 2-(Diethylamino... | CAS号150-13-0 对氨基苯甲酸 | CAS号100-37-8 二乙氨基乙醇 | CAS号27474-68-6 2-(diethylamino... | CAS号47662-72-6 2-(diethylamino... | CAS号59440-80-1 Benzoicacid, 4-... | CAS号6062-23-3 N-acetylpr°Caine | CAS号62276-02-2 methyl 4-(2,4-d... | CAS号63014-02-8 2-diethylaminoe...

2-Diethylaminoethyl P-Brombenzoat置于copper (II)-Fluoride,Sodium Azide,C.I.酸性橙108体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 24.0H,以63%的收率获得产物普鲁卡因
参考文献:基于芳基卤化物和叠氮基化合物之间碳氮偶联反应的一锅芳香胺化
标题:基于芳基卤化物和叠氮基化合物之间碳氮偶联反应的一锅芳香胺化
摘要:建立了各种芳基卤化物和叠氮基化合物之间有效的铜介导的c-N偶联反应,以产生相应的芳族伯胺.本发明的胺化显然涉及将叠氮基官能团还原成相应的伯氨基和以一锅法与芳基卤化物的交叉偶联反应.本发明的胺化可用于普鲁卡因的合成,一种局部麻醉药.机理研究表明2-氨基乙醇可以作为主要的氢供体,并且该反应将在不形成中间芳基叠氮化物的情况下进行.
DOI:10.1016/j.Tet.2011.12.058

专利信息

专利号:US-2025042888-A1
优先权日:2021-11-26
标题 :A process for the preparation of indolmycin and derivatives thereof
发明人：GULAM DASTAGER SYED; SHYAM SAID MADHUKAR; KHAN ABUJANAID; ARVIND KULKARNI AMOL
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN
摘要:The present disclosure relates to a new, simple, two step synthesis of Indolmycin and its derivatives of formula (I), in 4-5 hours. Formula (I) wherein said process comprising the step of: 10 (a) reacting indole derivative with methyl magnesium bromide in a suitable solvent at a temperature in the range of 0-30° C. followed by adding ethyl epoxy butanone in a suitable solvent at −20° C. for a period of 1-2 hrs and maintaining the obtained reaction mixture for 1 hr at −20° C. to obtain a compound; and (b) passing the compound obtained at step a), base and N-methylated quinidine 15 through solid-solid continuous flow reactor for 1 minute to obtain the compound of formula (I).

专利号:WO-2019049138-A1
优先权日:2017-09-11
标题:Methods for synthesis of resolvins
发明人：JAGTAP PRAKASH; SALZMAN ANDREW LURIE
权利人:SALZMAN INVEST LTD
摘要:The present invention relates to methods of chemically synthesizing a resolvin compound such as resolvine E1 (RvE1), or a pharmaceutically acceptable salt thereof; and chemically stable formulations of said compound.

专利号:US-6417374-B1
优先权日:2001-02-15
标题 :Process for the preparation of beta hydroxy-delta lactone using novel intermediates
发明人：GHORPADE SANDEEP RAGHUNATH; KALKOTE UTTAM RAMRAO; CHAVAN SUBHASH PRATAPRAO; BHIDE SUNIL RAMCHANDRA; RAVINDRANATHAN THOTTAPPILLIL
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(β-Hydroxy-δ-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.

专利号:WO-2025019775-A1
优先权日:2023-07-19
标题 :Endoxifen compositions and methods of use thereof and synthesis thereof
发明人：QUAY STEVEN
权利人:ATOSSA THERAPEUTICS INC
摘要:Described herein are endoxifen compositions comprising novel compounds and methods of use thereof. Methods of synthesis for the compositions are described herein. The endoxifen compositions described herein may exhibit aromatase inhibition activity or estrogen receptor activity. The endoxifen compositions described herein may be useful in the treatment of a condition in a subject, such as cancer.

专利号:SU-1120654-A1
优先权日:1983-01-27
标题 :Salts of mesidides of alpha-piperidincarboxylic acids possessing locallyanesthetic, antiarythmic and antifibrillatory activity and mesidides of alpha-puperidincarboxylic acids as intermediate products for synthesis of salts of mesidides of piperidincarboxylic acids

专利号:FR-2683455-A1
优先权日:1991-11-08
标 题 :COMPOSITION FOR STIMULATION OF LOCALIZED SYNTHESIS OF CONNECTIVE TISSUES.